Correlations between cholinergic neurons and muscarinic m2 receptors in the rat retina
作者:
Johan Wassélius,
Kjell Johansson,
Anitha Bruun,
Charles Zucker,
Berndt Ehinger,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1799-1802
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Choline acetyltransferase;Immunohistochemistry;Muscarinic m2 receptors;Rat;Retina;Vesicular acetylcholine transporter
数据来源: OVID
摘要:
ACETYLCHOLINE is well established as the neurotransmitter of starburst amacrine cells in the vertebrate retina but their function is poorly understood. We compared the distribution of muscarinic m2 receptors in the rat retina with the localization of the starburst cell processes. mAChR2 immunoreactivity appeared in a central band in the inner plexiform layer, which did not co-localize with the processes of the cholinergic amacrine cells. We found co-labelling of VAChT and ChAT making it highly unlikely that there are undetected cholinergic neurons in rat retina. Most mAChR2 receptors were located far from the cholinergic neurons, suggesting that most of them are unlikely to be associated with conventional cholinergic synapses.
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