Alpha-1-Antitrypsin (PI) Polymorphism in France, with Special Regard to thePI*ZAllele
作者:
R. Sesboüé,
J.P. Martin,
期刊:
Human Heredity
(Karger Available online 1991)
卷期:
Volume 41,
issue 5
页码: 340-346
ISSN:0001-5652
年代: 1991
DOI:10.1159/000154022
出版商: S. Karger AG
关键词: Alpha-1-antitrypsin;PI phenotypes;Deficiency;Allele frequency cline
数据来源: Karger
摘要:
Alpha-1-antitrypsin (PI) phenotypes were studied in a sample of more than 5,000 individuals from cities throughout France. Special interest was paid to the PI*Z allele whose average frequency, based on the present work plus results from the literature, was 0.0130. This figure was used to estimate the number of PI Z homozygotes in France. In accordance wtih previous studies, the frequency of the PI*S allele was found to increase towards the southern parts of France.
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