Enantiomeric HPLC Separations of 4-Substituted-Pyrrolidin-2-Ones using Cellulose Based Chiral Stationary Phases
作者:
Claude Vaccher,
Marie-Pierre Vaccher,
Jean-Paul Bonte,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 3
页码: 553-565
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542838
出版商: Taylor & Francis Group
关键词: Chiral pyrrolidin-2-ones;HPLC;Cellulose trisbenzoate
数据来源: Taylor
摘要:
Enantiomeric resolution of 4-substituted-pyrrolidin-2-ones were investigated on cellulose chiral stationary phase. The separations were made using normal phase methodology with a mobile phase ofn-hexane-alcohol (methanol, ethanol, 1-propanol or 2-propanol) in various proportions, and a silica-based cellulose tris-benzoate (Chiralcel OJ). The mobile phase was optimized to achieve the best resolution. Effects of variation of alcohol concentration, nature of aliphatic alcohols in the mobile phase were studied. The effects of substitution were analysed. Baseline separation was easily obtained in many cases. The maximum resolution factor obtained was near 7.50.
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