Murine Sarcoma Virus-Transformed Nonproducer Rat Cell Lines Resistant to Type C-Virus Infection
作者:
David M. Livingston,
George J. Todaro,
期刊:
Intervirology
(Karger Available online 1973)
卷期:
Volume 1,
issue 5-6
页码: 329-337
ISSN:0300-5526
年代: 1973
DOI:10.1159/000148861
出版商: S. Karger AG
关键词: Type-C virus;Nonpermissive cells;Phenotypic reversion
数据来源: Karger
摘要:
Two nonvirus-producing subclones of the murine sarcoma virus-transformed rat nonproducer cell, K-NRK Cl 32, which have partially regained the property of contact inhibition of cell growth, have been isolated. Both subclones, unlike the trans formed and untransformed parental cell lines, K-NRK Cl 32 and NRK, are resistant to exogenous infection by type-C RNA tumor viruses from several species; this block can be overcome at high virus input multiplicity. Iododeoxyuridine induction of endogenous rat type-C virus proceeds normally in spite of the block to exogenous viral infection.
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