Physiological Actions and Clinical Applications of Transforming Growth Factor-β(TGF-β)
作者:
RobertsAnita B.,
SpornMichael B.,
期刊:
Growth Factors
(Taylor Available online 1993)
卷期:
Volume 8,
issue 1
页码: 1-9
ISSN:0897-7194
年代: 1993
DOI:10.3109/08977199309029129
出版商: Taylor&Francis
关键词: tissue repair;fibrosis;carcinogenesis;immune cells;autoimmune diseases;bone
数据来源: Taylor
摘要:
AbstractIn the 10 years since its definition and characterization, TGF-βhas come to be accepted as the prototypical multifunctional peptide growth factor. Attempts to understand its mechanism of action on cells have resulted in conceptual advances in knowledge of the contextual nature of growth factor activities. These have included modulatory effects both of sets of growth factors and of the cellular environment, including extracellular matrix (Sporn and Roberts, 1990; Nathan and Sporn, 1991). Because of the breadth of the cellular targets and activities of TGF-βit is impossible to be comprehensive in review of its physiological roles. Rather, we will cover selected aspects with emphasis on physiological roles which might ultimately find clinical application. As much as possible, we will considerin vivoroles of TGF-βin the context of the inherent complexity of cell-matrix and cell-cell interactions characteristic of mixed cell populations, tissues, or organs.
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