Rotavirus and calicivirus infections of the gastrointestinal tract
作者:
Max Ciarlet,
Mary Estes,
期刊:
Current Opinion in Gastroenterology
(OVID Available online 2001)
卷期:
Volume 17,
issue 1
页码: 10-16
ISSN:0267-1379
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
Virus infections of the gastrointestinal tract, leading to gastroenteritis, are a common problem in both developed and developing countries. Rotavirus and Norwalk-like viruses are the most common agents responsible for clinically severe disease in humans, and this paper focuses on new information about the mechanisms of pathogenesis and epidemiology of these two pathogens. Rotavirus-induced disease involves a viral enterotoxin and activation of the enteric nervous system, as well as malabsorption, suggesting that common mechanisms of pathogenesis may exist between viral and bacterial pathogens. Each gastrointestinal virus possesses unique molecular properties that can be exploited to discover new information about responses of cells of the gastrointestinal tract. Work continues toward making vaccines for rotavirus and Norwalk-like viruses.
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