Hydrational and intrinsic compressibilities of globular proteins
作者:
D. P. Kharakoz,
A. P. Sarvazyan,
期刊:
Biopolymers
(WILEY Available online 1993)
卷期:
Volume 33,
issue 1
页码: 11-26
ISSN:0006-3525
年代: 1993
DOI:10.1002/bip.360330103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPartial compressibilities of globular proteins in water are reviewed. Contribution of hydrational and of intrinsic compressibilities to experimental partial quantity have been evaluated from ultrasonic data using two independent methods: (a) additive calculation of the hydrational contributions of the surface atomic groups and (b) an analysis of correlation between partial compressibility and molecular surface area. The value (14 ± 3) × 10−6bar−1for the isothermal compressibility coefficient of the protein interior at 25°C was obtained as an average value for variety of globular proteins. This value is similar to that of solid organic polymers. Possible relaxation contribution to partial compressibility is roughly estimated from comparison of thermodynamic with x‐ray data on protein compressibility. The average compressibility of water in the hydration shell of proteins was found to be 35 × 10−6bar−1, which is 20% less than that of pure water. © 1993 John W
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