Nineteen sorghum,Sorghum bicolor(L.) Moench, accessions were compared with the standard commercial cultivar ‘Northrup King Savanna 5’ for hard-dough stage panicle resistance to feeding by larvae of the fall armyworm,Spodoptera frugiperda(J. E. Smith). The biological variables measured to determine the differential development ofS. frugiperdaon diets containing florets of the sorghum genotypes were larval and pupal weight, duration of the larval stage, time to adult emergence, survivorship, fecundity, net reproductive rate, intrinsic rate of increase, and relative fitness. The plant introductions IS1340C, IS2246C, IS2403C, IS2553C, IS2569C, IS2825C, IS3477C, IS6911C, IS7007C, IS7498C, IS8337C, IS12219C, IS12592C, IS12612C, IS12617C, IS12662C, IS12664C, IS12666C, and IS12683C were all found more resistant than ‘Northrup King Savanna 5’, which is the most resistant commercial genotype available. Resistance in IS1340C, IS2246C, IS2403C, IS2553C, IS3477C, IS6911C, IS7007C, IS7498C, IS12612C, IS12662C, IS12664C, and IS12666C was primarily due to factors in the glumes (including lemmas and paleas). Chemical components in the seed were mainly responsible for resistance in IS2825C, IS12617C, and IS12683C, whereas factors in both seed and glumes were responsible for the resistance shown by IS12219C and IS12592G. Resistance was significantly correlated (r2>0.50,P<0.05,n= 16) with the concentration of acid detergent fiber and tannin in the seed.