Genetic Polymorphisms in HLA-A, -B, -C and -DR Antigens in Japanese Patients with Palmoplantar Pustulosis
作者:
H. Torii,
H. Nakagawa,
Y. Ishibashi,
K. Tokunaga,
T. Juji,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 4
页码: 290-292
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247168
出版商: S. Karger AG
关键词: Palmoplantar pustulosis;HLA antigens;Psoriasis
数据来源: Karger
摘要:
Genetic polymorphisms in HLA-A, -B, -C and -DR antigens were investigated in 78 unrelated Japanese patients with palmoplantar pustulosis (PPP) and compared with a total of 472 normal persons. Only HLA-DR9 showed a significantly increased frequency among all HLA antigens investigated (χ2 = 11.57, p < 0.001). It is suggested that major histocompatibility complex class II antigens including HLA-DR antigen may determine the susceptibility to PPP and PPP may be a distinct disease entity from psoriasis
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