Models of xenotransplantation tolerance
作者:
Leo Bühler,
David Cooper,
期刊:
Current Opinion in Organ Transplantation
(OVID Available online 2003)
卷期:
Volume 8,
issue 1
页码: 83-88
ISSN:1087-2418
年代: 2003
出版商: OVID
数据来源: OVID
摘要:
Induction of tolerance is likely to be necessary for the achievement of successful xenotransplantation, because immune responses against xenogeneic tissues or organs are vigorous. Currently, protocols that allow prolongation of xenogeneic grafts in preclinical large animal models are not clinically applicable, because the immunosuppressive regimens induce significant morbidity and mortality. This review focuses on the progress that has been made in the strategies that aim to induce donor-specific xenogeneic tolerance, which are largely based on the transplantation of thymic tissue, the induction of molecular chimerism, and the induction of mixed hematopoietic cell chimerism.
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