Ammonium Perchlorate Contamination of Colorado River Drinking Water is Associated With Abnormal Thyroid Function in Newborns in Arizona
作者:
Ross Brechner,
Gregory Parkhurst,
William Humble,
Morton Brown,
William Herman,
期刊:
Journal of Occupational and Environmental Medicine
(OVID Available online 2000)
卷期:
Volume 42,
issue 8
页码: 777-782
ISSN:1076-2752
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
The Colorado River below Lake Mead, which supplies drinking water for approximately 20,000,000 people, is contaminated by ammonium perchlorate. We identified populations who were exposed and unexposed to perchlorate-contaminated drinking water and compared median newborn thyroid-stimulating hormone (TSH) levels after adjusting for age in days at measurement and for race/ethnicity. Median newborn TSH levels in a city whose drinking water supply was 100% perchlorate-contaminated water from the Colorado River below Lake Mead were significantly higher than those in a city totally supplied with non–perchlorate-contaminated drinking water, even after adjusting for factors known or suspected to elevate newborn TSH levels. This ecological study demonstrates a statistically significant association between perchlorate exposure and newborn TSH levels. It suggests that even low-level perchlorate contamination of drinking water may be associated with adverse health effects in neonates and highlights the need for both further study and control of human low-level perchlorate exposure.
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