The renin–angiotensin system: An example of the study of linear peptides by x‐ray crystallography
作者:
Gilles Precigoux,
Mohamed Benkoulouche,
Serge Geoffre,
期刊:
Biopolymers
(WILEY Available online 1989)
卷期:
Volume 28,
issue 1
页码: 41-49
ISSN:0006-3525
年代: 1989
DOI:10.1002/bip.360280107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIn order to get information on the bioactive conformations of the endogenic renin substrate, a few peptide segments of angiotensinogen, along with a pepstatin analogue, were studied in the solid state by x‐ray crystallography. These results are compared with the conformations of acidic proteinase inhibitors observed at the level of the active site. Such a comparison allows us to point out some analogies and differences between the observed conformation for the peptide alone and the conformations on the active sites. The analysis of the results should be a good starting point for making hypotheses on the renin substrate bioactive conformation(s
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