Phase II Study of Interferon-α and All-Trans Retinoic Acid in Metastatic Renal Cell Carcinoma
作者:
Bernard Escudier,
Alain Ravaud,,
Dominique Berton,
Christine Chevreau,
Jean-Yves Douillard,
Yves-Pierre Dietrich,
期刊:
Journal of Immunotherapy
(OVID Available online 1998)
卷期:
Volume 21,
issue 1
页码: 62-64
ISSN:1524-9557
年代: 1998
出版商: OVID
关键词: Interferon-α;All-trans retinoic acid;Renal cell carcinoma, metastatic
数据来源: OVID
摘要:
Summary:Interferon-α is an accepted treatment for renal cell carcinoma, with a response rate -14%. Retinoic acid has been claimed to improve such a response rate when combined with interferon. We present the results of a phase II study combining interferona and all-trans retinoic acid (ATRA) in patients with metastatic renal cell carcinoma. Thirty-one patients who were not eligible for a trial of high-dose interleukin- 2 treatment (because of low performance status: 7 patients; prior immunotherapy: 11 patients; age 70: 8 patients, cardiac or respiratory failure: 4 patients; refusal for randomization: 1 patient) were enrolled in this study. Only one partial response was observed (3%). Despite the good tolerance observed with this association, ATRA does not improve the efficacy of interferon in this selected patient population (with poor prognosis). Such a treatment combination should not be further recommended in patients with metastatic renal cell carcinoma.
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