MACROPHAGE ELECTROPHORETIC MOBILITY TEST AS A SENSITIVE PROBE OF TRANSPLANTATION IMMUNITY IN MICE
作者:
MIROSLAV MALKOVSKÝ,
JAN BUBENÍK,
MICHAL BOUBELÍK,
PETR HAUSNER,
期刊:
Transplantation
(OVID Available online 1979)
卷期:
Volume 28,
issue 2
页码: 121-124
ISSN:0041-1337
年代: 1979
出版商: OVID
数据来源: OVID
摘要:
Transplantation immunity was examined in mouse H-2− and non-H-2-disparate strain combinations by the macrophage electrophoretic mobility (MEM) assay. Lymph node cells from the recipients rejecting histoincompatible skin grafts were incubated in the presence of solubilized histocompatibility antigens prepared from spleens of the graft donors. Product(s) of lymphocyte-antigen interaction in appropriate combinations (sensitized lymphocytes with the sensitizing antigen) significantly diminished the electrophoretic mobility of guinea pig macrophages in all of the histoincompatible strain combinations examined. The data indicate that transplantation immunity in mice can be detected by the MEM assay.
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