Aggravation of Penicillin‐Induced Epilepsy in Rats with Locus Ceruleus Lesions
作者:
Herman C. Sullivan,
Ivan Osorio,
期刊:
Epilepsia
(WILEY Available online 1991)
卷期:
Volume 32,
issue 5
页码: 591-596
ISSN:0013-9580
年代: 1991
DOI:10.1111/j.1528-1157.1991.tb04697.x
出版商: Blackwell Publishing Ltd
关键词: Norepinephrine;Experimental epilepsy;Locus ceruleus
数据来源: WILEY
摘要:
Summary:The rate and pattern of development of seizures induced by penicillin injected intraperitoneally were determined in rats that had been depleted of brain norepinephrine (NE) by bilateral injections of the neurotoxin 6‐OH dopamine into the locus ceruleus. Behavioral observations and scalp electrographic recordings were made after injection and the efficacy of NE depletion was determined by high performance liquid chromatography measurement of cortical levels of NE and its metabolites. We found that in comparison to sham‐operated control rats, NE‐depleted rats had a significantly shorter latency to first observable myoclonic jerk, the first epileptic discharge, the first convulsion with sustained epileptic discharges, and a longer duration of convulsions. We observed a similar electrographic pattern of multifocal spikes with bilateral synchrony in both groups. However, more of the control rats (six of 12) had convulsions as compared to the lesioned rats (four of 12). These findings are consistent with previous evidence that depletion of neocortical NE facilitates the development of epileptiform activity in the CNS; however, a convulsive state was not induced by NE depl
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