摘要:

In Parkinson's disease as well as presenile dementia there is a dopamine deficit in the basal ganglia. Extrapyramidal symptoms are common in presenile dementia, and dementia is a common trait in Parkinsonism. It is reasonable to suggest a partial common etiology and pathophysiology, and the logical consequence is an investigation of levodopa substitution in presenile dementia. Unitil now very few reports of such studies have been published. The investigations have been uncontrolled or carried out on small or inhomogeneous materials. This investigation is triple‐blind, clinically controlled, and the material is very homogeneous. After 6 months' levodopa treatment no significant effect is shown either on a broad spectrum of psychiatric items or in cognitive functioning. This negative result is discussed. The probability of a specific Parkinson dementia is mentioned and the significance of the modifying effect of an imbalance in other transmitter systems is emphasize

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00139.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A model of clinical decision according to Bayes's formula is described and the problem of redundant informations is evaluated. It is postulated that a definitory and a syndromatic redundancy are unavoidable, which is why it is necessary to develop a correction factor. A series of indicants is investigated in two populations, and it is shown that correction for redundancy results in far‐reaching changes in the patterns of information. The permissible syndrome is defined: a subset of informations containing the necessary and sufficient predictive capacity.The methods described may be used for an evaluation of common syndromes and may enable comparisons of information patterns, related to identical or different criteri

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00140.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

In a sample of 205 hospitalized schizophrenics, 59 men were found who made verbal threats to kill or physical attacks sometime during their illness. All homicidal aggression occurred during active phases of psychosis, typically in a setting of acute excitement and in recurrent illnesses. Paranoid diagnoses were overrepresented. Closely related females were the prime targets, suggesting a resentment of dependence on a woman. An impersonal, compulsive urge appears to be the motviating force leading to physical attacks.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00141.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A controlled study on the effect of synthetic Thyrotropin‐Releasing Hormone (TRH) versus placebo in 10 drug‐free chronic schizophrenics is presented TRH 600 μg or placebo was administered intravenously on 4 consecutive days in a double‐blind cross‐over design and the schizophrenic symptoms were scored daily by use of two rating scales (CPRS and NOSIE). Blood samples were taken before and 30 and 45 minutes after the first and the fourth injection an analyzed for TSH. No changes in symptom intensity were found during the TRH or placebo treatment period and no difference was obtained between the two treatments. The dose of TRH used caused a significant increase in the plasma level of TSh which indicated a normal pituitary responsiveness to TRH. The data do not support the notion that TRH has a beneficial effect in chronic schizophrenic

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00142.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10808.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10809.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10810.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10811.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10812.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10813.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY