摘要:

Two generations of women were studied to clarify the influence of a woman's own preterm delivery or intrauterine growth retardation on her later risk of delivering preterm or growth‐retarded infants. The first generation consists of the cohort of women who gave birth at the National University Hospital (Rigshospitalet) in Copenhagen from 1959 to 1961 and the second, those of their daughters that have delivered themselves. The background of the study and the procedures involved are described. The percentage of data obtained and the preliminary findings concerning the relationship between social and demographic factors and the willingness of subjects to participate are include

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1993.tb05362.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A number of studies, including the Danish adoption study, have shown that, in adults, the familial resemblance of obesity, as measured by the body mass index (weight in kg/(height in m)2), is mainly due to genes. The body mass index may reflect both fat and fat‐free body mass. In this further analysis of the Danish adoption study, the degree of obesity was assessed by a silhouette score. There was a significant relationship in scores between the adult adoptees and their biological mothers and between the adoptees and their biological full siblings reared by the biological parents. Weaker, nonsignificant associations were found for the biological fathers and for the maternal and paternal half‐siblings. There were no relationships in silhouette scoring between adoptees and adoptive parents. The results confirm the results of our previous analysis of body mass index. We conclude that human obesity is under genetic control, whereas the childhood family environment has little, if any, influence on obesity in adults. It is an important task for future research to identify the genes invol

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1993.tb05363.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

During the past 30 years, the Danish Adoption Registry has been used in the analysis of the effect of genes and family environment on the development of mental disorders. During the last 15 years, the registry has also been used for similar analyses of somatic disorders, including obesity and premature death from somatic disorders. This article discusses the potential problems generally related to inference on morbidity from mortality data and particularly when using mortality data in adoption studies. We conclude that further insight into the question of nature, nurture or both requires extending the studies to include morbidity data as well as mortality data. We suggest that expanding the study by including biological and adoptive siblings and by using recently developed statistical methods will considerably strengthen the adoption study of morbidity and mortality.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1993.tb05364.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Methodological questions in heredity‐environment studies are discussed with special emphasis on schizophrenia and severe affective disorder. Mental disorder is a matter of behavioral and experimental manifestations, caused by complex interactions of genes and environment operating over a lifespan. It is therefore necessary to combine different research strategies in order to advance this field. However, progress in research is hampered by problems in classification and definition of phenotype. Accordingly, family, adoption and twin studies have a lot to contribute before molecular genetic research might be carried ou

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1993.tb05365.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY