摘要:

Inpatient treatment for anorexia nervosa can be necessary for medical, psychosocial or psychotherapeutic reasons. In general, these patients are characterized by “negative” selection characteristics (illness duration, failures of previous treatments, unfavourable natural milieu, poor motivation, etc.). An inpatient treatment program, in which 145 female patients have been admitted, is described. It consists of two phases: a first “symptom directed” phase aiming at weight restoration and normalization of eating, based mostly on behavior therapy principles; in a second “problem oriented” phase, patients are oriented either towards outpatient treatment (family therapy, individual psychotherapy), or, in the majority of the described cases, to an inpatient psychotherapeutic community program. The difficulties of this approach and some outcome results at long‐term follow‐u

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00908.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00314.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00315.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The antidepressant and biochemical effects of femoxetine, a selective serotonin uptake inhibitor, and desipramine, a selective nor‐adrenaline uptake inhibitor, have been compared in a double–blind study in 42 outpatients with depressive illness. The patients were allocated at random to treatment with either 600 mg femoxetine or 150 mg desipramine daily for 6 weeks. The total depression score showed a significant decrease in both groups, indicating an overall improvement in depressive symptoms. The patients treated with femoxetine reported significantly less severe anticholinergic effects during the whole treatment period than the desipramine patients. Both drugs decreased the level of 5‐HIAA in CSF, whereas no consistent changes were found in the HMPG and HVA levels. The pretreatment level of the metabolites had no predictive value for the outcome of the treatment with either drug. No significant correlation was found between therapeutic effect and the plasma concentration of the active comp

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00909.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00316.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00317.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The dexamethasone suppression test based upon analysis of 11‐deoxycorticosterone, corticosterone and cortisol was applied to 20 female depressed patients (10 endogenous, 10 neurotic) and 10 healthy controls. Calculating ratios of corticosterone to its biological precursor 11‐deoxycorticosterone allows to assess the activity of adrenal 11β‐hydroxylase. This enzyme activity depends on the mean secretion rate of ACTH. The preliminary data indicate that the sensitivity of the test may be increased when based on this enzyme activity rather than upon plasma cortisol concentrations. The decrease of 11‐deoxycorticosterone, a potent mineralocorticoid in relation to corticosterone may contribute to the reduced urine concentrating capacity in patients with endogenous de

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00910.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00318.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The Hamilton Rating Scale for depression (HDRS) has become the standard observer rating scale for depression, yet there are no adequate data from normal samples. The present study was carried out in northern Italy. The purposes were 1) to examine the ratings in normals and 2) to examine the scale's validity in a different language and culture. The scale was used in 40 normals and 40 depressives who were matched. Two self‐rating scales of depression were administered: the Symptom Rating Test and the Symptom Questionnaire. The results show that the HDRS is a valid mea‐ sure in that it sensitively discriminates between depressed patients and normals. The findings supportHamilton'sview that only the first 17 items of the scale are appropriate for computing the score. The use of self‐rating scales yielded additional information. The misclassification rate of the Symptom Rating Test was similar to that of the HDRS. The combined use of Research Diagnostic Criteria (RDC) and HDRS appears to be more reliable for the selection of depressed patients for research than the RDC

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00911.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Sixty per cent of the patients referred to two gastroenterological clinics and diagnosed as suffering from the irritable bowel syndrome (IBS), were found to have significant psychoneurotic morbidity on the basis of the General Health Questionnaire. A double‐blind, completely randomised, placebo controlled comparison of treatment with a combined anxiolytic/antidepressant (Motipress) found a significantly better effect of Motipress than placebo on diarrhoea and abdominal pain. Detailed analysis of the results suggests that there is no direct relationship between psychoneurotic illness and IBS, but the presence of the former has an adverse effect on the shortterm outcome of the bowel disorde

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1982.tb00912.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY