ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02065.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA modification of an earlier rating scale for extrapyramidal system disturbance is described, and evidence for the validity and reliability of the scale is presented. The usefulness of the scale in studies of neuroleptic drugs is discussed. By its application it is possible to quantify extrapyramidal side effects and to separate them into four principal factors.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02066.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYUnder double‐blind conditions, increasing amounts of perphenazine, or a perphenazine‐amitriptyline combination, were given to chronic schizophrenic patients already receiving “optimal” therapeutic dosages of perphenazine. Slight behavioral improvement was obtained in both groups, but a significantly smaller amount of extrapyramidal side effects was noted in the group receiving the combination. A double‐blind crossover study was used, which eliminated any order effect. The implications of these findings for therapy are briefly

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02067.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA controlled study of the relationship between the therapeutic response to a neuroleptic drug and the handwriting changes which it produces is described. Patients whose handwriting had changed as described by Haase improved to a greater extent than those whose handwriting had not changed, but received much larger doses of the drug. Patients treated according to the psychiatrist's judgment received larger doses than those which produced handwriting changes, but in retrospect the optimum dose corresponded closely to the dose producing handwriting changes. These findings are discussed.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02068.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYThe treatment of two groups of chronic schizophrenic patients is described. One was treated according to Haase's concept of the neuroleptic threshold, the other according to the clinicians judgment. The groups were randomly selected and all evaluation was done under double‐blind conditions. After a suitable interval the treatment procedures were reversed. There was no difference between the groups in the therapeutic results, but the group treated according to the neuroleptic threshold received significantly smaller doses. These results are discusse

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02069.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYA series of four experiments designed to assess the effect of antiparkin‐sonism drugs on phenothiazine produced parkinsonism are described. It was difficult to distinguish the effects of the active drug from placebo when intravenous injections were employed, but using handwriting as an indication it was possible to distinguish the oral administration of Benztropine Mesylate from a placebo. The results are discussed and it is concluded that trials of intravenous preparations in the treatment of parkinsonism are likely to be invali

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02070.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

SUMMARYDystonic reactions and more complex phenomena which appear to be related to them are described and illustrated with case material. The relationship of these phenomena to those of hysteria is discussed. An approach which abolishes artificial distinctions between the organic and the functional is suggested.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1970.tb02071.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY