摘要:

Abstract.The haemolytic activity of complement was evaluated in the serum of healthy children from birth to 2 years of age using the kinetic method for the determination of the time needed to lyse 50 % of target red cells (t 1/2). No sex‐linked differences were observed in any of the age groups studied and the lowest lytic activity levels for both complement pathways were detected in neonates. The two pathways, however, showed different maturation patterns, i. e., lytic activity levels similar to those of adults were reached between the 1st and 3rd month of life (classical pathway) and around the 13th month (alternative pathway). In the age group of 7 to 24 months, the lytic activity of the classical pathway was higher than in adults. The present data permitted us to establish normal ranges of t 1/2 values for the classical and alternative pathways in serum of healthy neonates and children aged 1 to 24 month

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11464.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract.Quantification of platelet‐bound immunoglobulin is widely used in the evaluation of thrombocytopenia. Several methods have been devised among which labelled ligand‐binding assays seem to be most appropriate. In series of adult patients such assays have been shown to be superior in separating immune‐thrombocytopenia from thrombocytopenia of non‐immune causes. We studied 62 children with thrombocytopenia of various causes, using radiolabelled protein A as a ligand to measure platelet‐surface bound IgG. The test was highly sensitive (93%) in detecting immune‐thrombocytopenia. The specificity, however, was only 57 %, which is less than in published studies of adults. In a number of cases presumed to be non‐immune‐thrombocytopenia, notably a few patients with leukaemia and bone marrow aplasia, we found increased amounts of platelet surface‐bound IgG. The significance of this finding is not clear. An indirect assay measuring platelet‐specific IgG in plasma was less sensitive (46 %) but highly specific for immune‐thrombocytopenia (89 %). The measurements of platelet‐surface‐bound IgG and platelet‐specific IgG in plasma are of limited diagnostic value in childhood thrombocytopenia but are useful in following t

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11465.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract.We performed analyses of electrolytes, amino acids, albumin, alpha2‐macroglobulin, gamma‐globulin and LDH in the lumbar cerebrospinal fluid of children undergoing treatment for acute lymphoblastic leukemia, non‐Hodgkin‐lymphoma or acute myeloid leukemia. At the time of diagnosis signs of a disturbance of the blood‐brain barrier were found in some patients. During induction treatment with L‐asparaginase a rise of glutamic acid and a decrease of glutamine occurred. This finding correlated with slowing of the EEG. Treatment with vincristine was associated with a slight drop of sodium and chloride concentration in serum, but not in the cerebrospinal fluid. Central nervous system prophylaxis with cranial irradiation, and to a lesser degree with intravenous medium‐dose methotrexate, gave rise to a further deterioration of the blood‐brain barrier function as indicated by an increase in albumin, alpha2‐macroglobulin and LDH levels. During radiotherapy the concentration of several amino acids rose, probably due to a disturbance of active carrier mechanisms. Patients with elevated albumin at the end of radiotherapy more often suffered an early leukemia relapse while still on treatment. No other clinical or electroencephalographic correlations of altered barrier functi

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11466.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract.IgE antibodies to Pityrosporum orbiculare and 16 other species of fungi were measured with the radioallergosorbent test (RAST) in sera of 131 children. The children were 7‐18 years old, suffered from atopic diseases and showed a varied allergic profile on a skin prick test (SPT). IgE antibodies to P. orbiculare were found in the sera of 26 of the 131 children. A higher proportion of the P. orbiculare RAST positive children than of the negative ones had current eczema (p500 kU/1 had serum IgE antibodies to P. orbiculare. Twenty‐four of the 26 P. orbiculare RAST positive children harboured serum IgE antibodies to other fungi. The strong relationship between atopic eczema and the occurrence of IgE antibodies to P. orbiculare indicates that these antibodies may be pathogenetically important in at least some patients with atopic eczema and this gives another dimension to this common skin dise

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11467.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract.Fungal cultures were negative in 20 children aged 1 to 14 years with a clinical picture consistent with juvenile plantar dermatosis. During the same period (April 1987 to August 1988) 4 cases of tinea pedis were seen in the same age group. The important difference between juvenile plantar dermatosis (with or without associated atopic disease) and the clinical picture seen in dermatophytic infection is described.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11468.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract.The hypothesis that low‐level lead absorption is a risk factor for learning disabilities in school children was examined in the municipality of Aarhus, Denmark. During 1982‐1983, a total of 1302 children in the first grade (54 % of the eligible population) delivered shed deciduous teeth. The lead concentration in the circumpulpal dentin was used as an indicator of the cumulated lead absorption, and 200 cases (high‐lead) and controls (low‐lead) were selected, and matched for socioeconomic group and gender. The parents were interviewed regarding the child's development and past medical history. Possible confounders were identified and controlled for in a logistic multivariate model. The influence of lead absorption became statistically signincant only after exclusion of the children with proven medical risk factors, thereby the adjusted odds ratio in the weighted analysis was changed from 2.2 to 4.3. Thus, in a Scandinavian low‐level lead‐polluted area, lead absorption appears to be a risk factor for learning d

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11469.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11470.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11471.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11472.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1990.tb11473.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY