摘要:

SUMMARYA brief historical outline is given of the development of the concept of purpura fulminans, and the differential diagnosis is mentioned.The writer reports the case of a previous healthy, sucking infant, 3 weeks old, who died within 48 hours after the appearance of the first symptoms of the lesion. Autopsy revealed the presence of a streptococcal sepsis, presumably originating from an infected diaper rash.On the basis of the literature, it is pointed out that it is most likely that the classical purpura fulminans usually, perhaps always, is an expression of a streptococcal sepsis. The therapeutic consequence of this will be at once ‐ at the very first observation of the lesion ‐ to institute an energetic chemotherapy; and treatment with penicillin should never be omit

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1947.tb03695.x

出版商:Blackwell Publishing Ltd    

年代:1947

数据来源: WILEY

摘要:

SUMMARYReport of a case of feminine pubertas praecox: at the age of 7 months the child started growth of the breasts and pubes, and ever since she has menstruated regularly. When she was 31/iyear old, she measured 108 cm, and her bone development was equivalent to that of a 10 year‐old child. She looks like a small girl at puberty. After a discussion of the different types of feminine pubertas praecox, it is assumed that the child belongs to the so‐called constitutional type, though the presence of anatomical changes of probably benign nature in the hypothalamus cannot be preclu

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1947.tb03696.x

出版商:Blackwell Publishing Ltd    

年代:1947

数据来源: WILEY

摘要:

SUMMARYThe following findings were made in a boy, aged 12 years, who since the age of 2 to 3 years has suffered from excessive thirst and polyuria (at present 4 to 5 liters daily) and who was considered to be suffering from diabetes insipidus:1) No effect of the hormone of the posterior lobe of the pituitary body.2) Normal urine and normal blood‐pressure, but increased blood urea and greatly decreased renal function.3) The urea clearance identical with the inulin clearance, which is a remarkable fact not previously described.4) The views on the excretion of urea are mentioned.5) On injection of insipidin results were found which are supposed to support the theory of the back passage of urea in the tubuli by means of active cellular activit

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1947.tb03697.x

出版商:Blackwell Publishing Ltd    

年代:1947

数据来源: WILEY

摘要:

SUMMARYThe author gives an account of experiences in further investigations into the occurrence of palpable spleens in healthy new‐born infants and in healthy infants below the age of six months. The results were as follows:1) 1060 clinically healthy new‐born infants, with birth weights of at least 2 900 g were each examinedonceduring the first week of life to establish the occurrence of palpable spleens. The frequency of positive palpation findings shows an evenly rising tendency up to and including the third day of life, after which it steadily declines step by step. The results agree very well, even when statistically analysed, with a series published earlier by the present author, in which all the children were subjected to daily examinations of the spleen during the first week of life. Both the investigations series thus show that the frequency of positive spleen palpation findings exhibits a statistically verified maximum on the third day after birth. The average frequency of positive palpation findings in the new series is 32.1 ± 1.4 %, the maximal frequency on the third day of life is 45.5 ± 4.0 %.2) Healthy infants, above the new‐born age, show a frequency of positive spleen palpation findings which in the case of children younger than three months is 17.7 ± 3.6 % and for children between three and six months is 14.9 ±4.4 %. The former series comprises 113 children, the latter 67. Statistically there is good agreement between the frequency of positive spleen palpation findings in healthy infants below the age of three months and that in children between three and six months of age.3) There is a statistically verified difference between the average frequency of positive spleen palpation findings in healthy new‐born infants, on the one hand, and in infants at ages between the new‐born period and six months, on the other. Thus in healthy new‐born infants a positive spleen palpation finding is considerably more usual than in other infants below the age of six months.4) The author emphasizes the necessity of care and practice in spleen palpation on infant children. Further, the dynamic conditions which characterize the physiological enlargement of the spleen are emphasized. The enlarged spleen found in the case of pathological conditions in the new‐born and in healthy infants is often more voluminous and of firmer consistency and therefore easier to observe than in the clinically healthy in the same age‐group. Nevertheless in infants which are entirely free from any signs of disease there is not infrequently a relatively large and firm palpable spleen. This is true particularly of

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1947.tb03698.x

出版商:Blackwell Publishing Ltd    

年代:1947

数据来源: WILEY