ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17212.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17213.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17214.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17215.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17216.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb11267.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACT.Merriam, G.R., Ma, N., Liu, L., Wachter, K.W. and Libre, E. (Reproductive Endocrine Unit, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA). Acta Paediatr Scand [Suppl] 349: 167, 1989.Although the different anterior pituitary hormones are generally considered to be regulated independently, examination of their patterns in blood suggests that pulsatile secretion of several of these hormones may be synchronized. Traditional methods of cross‐correlation analysis may not be adequate for quantifying this linkage. Since some simultaneity may arise by chance, expected rates of random coincidences must also be estimated to determine if apparent concordance rates significantly exceed those due to chance. A method of estimating linkage by counting simultaneous and near‐simultaneous events within temporal‘windows’of varying width is proposed and tested against 11 series of luteinizing hormone (LH) and prolactin measurements from normal men. Rates of concordance in series drawn from different subjects rather than the same subject, or series scrambled in time, do not contain meaningful simultaneous events and so can be used to estimate the rate of random synchrony. By these standards, a clear excess of concordant prolactin and luteinizing hormone (LH) peaks was observed in normal men, suggesting significant physiological synchrony between these pulses of secretion. This method can be applied to a variety of hormonal

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb17217.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTInternational Board, Kahi International Growth Study (Kahi, Stockholm, Sweden). Update on the Kahi International Growth Study, April 1989. Acta Paediatr Scand [Supp] 356: 173, 1989.The efficacy and safety of recombinant human growth hormone (rhGH) treatment is under prospective evaluation in children with various short stature conditions. Of the 987 children enrolled up to April 1989, 836 (84.7%) had classic growth hormone deficiency (GHD) and 151 (15.3%) non‐GHD. There was a predominance of idiopathic growth hormone deficiency (IGHD), with a ratio of IGHD to secondary or organic GHD (OGHD) of 2.2:l. There were more boys than girls in both the IGHD and OGHD groups. Isolated GHD was more common than multiple pituitary hormone deficiency except in some of the groups with OGHD. About half of the OGHD patients had GHD secondary to treatment for CNS tumours. Idiopathic short stature and Turner's syndrome were the most common diagnoses in the non‐GHD group. The median age at onset of treatment in IGHD was 8.2 years for boys and 8.6 years for girls. The corresponding figures for OGHD were 14.0 years and 12.2 years, respectively. The height SDS for chronological age at the start of treatment was ‐3.0 for IGHD and slightly less for children with OGHD. Approximately one‐third of the children had already reached puberty at the start of hGH tr

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb11268.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

ABSTRACTInternational Board, Kabi International Growth Study (Kabi, Stockholm, Sweden). Parental heights of children with idiopathic growth hormone deficiency: analysis from the Kabi International Growth Study. Acta Paediatr Scand [Suppl] 356: 178, 1989.In an international study of children treated with growth hormone (GH), parental heights of 554 children with idiopathic growth hormone deficiency (IGHD) and of 248 children with secondary or‘organic’growth hormone deficiency (OGHD) were ascertained. The maternal height SDS of IGHD children was ‐0.41 ± 1.26 (mean ± SD) and the maternal height SDS of OGHD children was 0.03 ± 1.11 (p<0.006). Paternal height SDS of IGHD children was ‐0.19 ± 1.08, and paternal height SDS of OGHD children was 0.15 ± 1.08 (p<0.006). Adverse deliveries were associated with significantly shorter mothers (p= 0.04) and a greater discrepancy between paternal and maternal heigh

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb11269.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1989.tb11233.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY