摘要:

Summary1. The pattern of sulphate acceptors present in the urine of phenylketonurics and control cases was visualized by chromato‐autoradiographic methods, after treatment of urine specimens in a sulphur ‐ylating rat‐liver system in the presence of S35‐labelled sulphate.2. The sulphate of o‐HPAA formed during this procedure from o‐HPAA excreted in the urine of phenylketonurics could be demonstrated as a well‐defined spot (pk 1) on the autoradiograms in all untreated cases.3. Another sulphate acceptor, revealed after acid hydrolysis, was shown to be identical with the hydantoin formed from urea andp‐HPPA during hydrolysis. The concentration of the ester sulphate of this hydantoin (pk 2) probably reflects the amount ofp‐HPPAexcreted in phen‐ylketonuria. This compound did not vanish from the urine specimens of patients given a low‐phenylalanine diet for periods of up to 13 months. It was, however, absent in one case treated for 29 months. The significance of these findings, as well as the possibilities of the method a

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08045.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

SummaryTwo patients with aplastic anemia (one of them suffering from familial Fanconi anemia) are presented, in whom treatment with anabolic steroids and corticosteroids resulted in marked improvement. Our limited experience indicates that methan‐drostenolone produces much fewer side effects and may be as effective as testosterone in this conditio

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08046.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

SummaryA new experimental system for study of higher nervous function has been tested with 23 normal fullterm infants. This method employs conditioned rotation of the head recorded electro‐mechanically. As compared with conditioned sucking studies, this method has been found advantageous from several points of view. New data on the development and coordination of motor responses in young infants have been obtained. A sufficiently stable conditioned reflex may be achieved at 66 weeks of age, differentiation of two positive stimuli at 3 months and double reversal of this differentiation in the 4thmonth. The experimental approach described permits study and comparison of two analogous symmetrical heterolateral reflexes and simple analysis of intensity and latency of response as sensitive indicators of cortical functions. It also opens new possibilities for the study of early purposive motor reactions. Since rotation of the head may take on various meaning —food‐seeking, orientation, defense—it is particularly well suited to the study of ontogenetic change of one simple motor act into a complex adaptative me

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08047.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

SummarySera from children with ulcerative colitis haemagglutinate sheep red blood cells coated with phenol‐water extracts of human colon, liver or kidney. It was found that the haemagglutination ofcolon‐coatedcells could be completely or partially inhibited by previous absorption of the sera with extracts of colon, liver or kidney. Likewise, the haemagglutination ofliver‐coatedcells could be inhibited by means of extract from colon or liver. The results indicate that liver and colon contain at least one immunologically identical or similar antigen. In addition, certain preliminary results suggest that the sera contain antibodies against several distinct antigens, some of which are present only in the extracts of colon and not in those of liver or k

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08048.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

SummaryThe concentration of fibrinogen in the plasma of 39 infants during the neonatal period was determined by Morrison's syneresis method as modified by Blom‐back. The samples were drawn from the umbilical vein by catheterization. The results, expressed in mean and standard error of the mean, were as follows:A. Healthy full‐term infants at birth: 225 ± 10.0 mg/100 ml.B. Healthy full‐term infants during third to sixth day of life: 322 ± 21.2 mg/100 ml.C. Erythroblastotic infants at birth: 271 ± 14.7 mg/100 ml.D. Hyperbilirubinemic infants without blood‐group incompatibility during third to sixth day of life: 297 ± 30.0 mg/100 ml.No statistically significant difference was found between healthy and erythroblastotic or hyperbilirubinemic infants as regards concentration of fibrinogen in

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08049.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08050.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

Summary1. The day‐today physiological variations of the lung volumes were studied in healthy boys and girls. The results were compared with the ones obtained in healthy adults.2. The most striking variation was observed for the values of expiratory reserve volume which evokes the cooperation of the children and for the values of residual volume (because its calculation is a function of VER

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08051.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

Summary1. When a solution of sodium and potassium phosphates at pH 7.4 were administered to normal breast‐fed infants aged 5, 6 and 7 days, they excreted considerably more H ions (in the form of titratable acid).2. After the administration of a single dose of an acidifying drug normal breastfed infants 7 days old (a) raised the [H+] × 10‐7of their urine less rapidly and completely than adults, (b) excreted less of the H ions generated by the drugs but (c) excreted almost as much ammonia/kg of body weight.3. The administration of neutral phosphates to adults (a) made no difference to the rate and extent of the rise of [H+] × 10‐7after ammonium chloride, (b) increased the excretion of H ions in the form of titratable acid without reducing the excretion of ammonium ions. After giving phosphates to the infants they (a) maintained the [H+] × 10‐7of the urine at a lower level, (b) increased the excretion of free H ions but (c) reduced the excretion of ammonia and consequently (d) did not increase the excretion of free H ions + ammonia so much as adults.4. The normal breast‐fed infant appears to be handicapped in dealing with a sudden acidosis by (a) an inability to raise the [H+] × 10‐7of the urine rapidly and completely, (b) an absence of urinary buffers, (c) an overall failure to excrete H ions so rapidly as adults. This may amount to a general deficiency on the part of the kidney to produce the necessary H ions

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08052.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

摘要:

SummaryA preliminary report is given of 5 cases of infantile hydrocephalus where ventriculo‐venous shunt operations using the Spitz‐Holter technique were performed. There were no postoperative deaths. In all cases pre‐ and postoperative measurements of head circumference, pneu‐mography of the ventricular system, recordings of the ventricular fluid pressure and examinations by pediatricians with regard to mental and physical development were performed. The follow‐up time ranged between 6 and 12 months. Three reoperations of the shunt were necessary in two patients, after which all valves were functioning well. In all 5 cases interruption of the rapid increase in the head circumference occurred and a low ventricular fluid pressure was found postopera‐tively. In 4 cases postoperative pneumo‐graphy suggested an incress? in brain bulk. Normal mental development was found in 4 of the cases.In addition a brief report is given of a case of increased intracranial pressure due to diffuse melanosarcomatosis of the meninges in an adult. In this case a Spitz‐Holter shunt operation reduced a preoperatively high and widely fluctuating ventricular fluid pressure to a low, even level during an observation time of 6 months. It is suggested that the Spitz‐Holter operation may be of benefit in cases of severe intracranial hypertension where removal of an intracranial tumour or an intracranial shunt operation doe

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08053.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1961.tb08054.x

出版商:Blackwell Publishing Ltd    

年代:1961

数据来源: WILEY