ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07109.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07110.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Boulton, T. J. C. (Department of Paediatrics, University of Adelaide, The Adelaide Children's Hospital, South Australia). Serum cholesterol in early childhood: Familial and nutritional influences, and the emergence of tracking. Acta Paediatr Scand, 69: 441, 1980.—The influence of familial and nutritional factors on serum total cholesterol (TC), and the age at which evidence of tracking appeared, was investigated in the first 2 years. The level of association between the parents' and children's TC levels increased to age two (r0.25,p<0.001), being slightly greater for the boys than for the girls. This was paralleled in the results for low density lipoprotein cholesterol (LDL), but weak association only occurred for high density lipoprotein cholesterol (HDL). Comparing the relative influence on the children's TC of nutritional and familial factors, the parents' TC levels and a family history of early coronary heart disease were found to be important correlates of the children's TC. Low correlations occurred for nutritional factors. The degree of tracking of cholesterol (the extent to which the level maintains its relative position in the distribution curve through time) as measured by the correlation coefficient of the level at time one on the level at time two, increased through infancy tor0.40 from one to two years. The association between the TC level in cord blood and later levels increased to two years (r0.32). The results are interpreted as showing either familial influences on a child's TC level become increasingly important from the end of the first year, or that the effect of these influences is obscured during infancy by other, presumably nutritional, factors which themselves are elusive because of the inherently inadequate methodological techniques of dietary studie

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07111.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Andersen, G. E. and Johansen, K. B. (the Neonatal Department, Rigshospitalet, University of Copenhagen, Denmark). LDL receptor studies in children with heterozygous familial hypercholesterolemia (FH): Measurement of sterol synthesis in blood lymphocytes. Acta Paediatr Scand, 69: 447, 1980.—Sterol synthesis was measured in lymphocytes from 48 members of 10 families with familial hypercholesterolemia (FH) under three sets of conditions. First the synthesis of LDL receptors and sterols were maximally stimulated by incubation of lymphocytes in lipoprotein‐deficient serum. Secondly sterol synthesis was suppressed by the addition of LDL and thirdly sterol synthesis was maximally suppressed by the addition of 7‐ketocholesterol. In five of the ten families LDL suppression of sterol synthesis in FH heterozygotes was only about half of the LDL suppression in normals. In four families, however, there was a considerable overlapping of LDL suppression in FH heterozygotes and normals. Finally in one family LDL suppression was strictly normal in FH heterozygotes who thus appear to have a different type of FH not involving an impaired LDL receptor fun

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07112.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Andersen, G. E. and Johansen, K. B. (The Neonatal Department, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark). Fatty acid composition of serum low density lipoprotein‐ and lymphocyte cholesterol esters in children with heterozygous familial hypercholesterolemia. Acta Paediatr Scand, 69:453, 1980.—The content of free and esterified cholesterolin serum low density lipoprotein (LDL) was measured in 19 children with heterozygous familial hypercholesterolemia (FH) and in 10 normal siblings. In FH both free and esterified cholesterol were found to be elevated. Furthermore the fatty acid composition of serum LDL‐ and lymphocyte cholesterol esters was determined. However, no difference was found between FH heterozygotes and normals thus indicating that LDL‐hypocatabolism typically found in FH does not correlate with an abnormal fatty acid composition of LDL‐cholesterol esters nor with an impaired cholesterol esterification intracellularly in ly

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07113.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Settergren, G., Lindblad, B. S. and Persson, B. (Department of Paediatrics, Karolinska Institutet and the Unit of Paediatric Anesthesiology, St. Göran's Hospital, Stockholm, Sweden). Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate and amino acids in anesthetized children. Acta Paediatr Scand, 69: 457, 1980.—Cerebral blood flow (CBF) and cerebral av differences of oxygen, glucose, 3‐hydroxybutyrate, acetoacetate, lactate, pyruvate and amino acids were measured in anaesthetized children before elective surgery in order to study possible age‐dependent variations. CBF was measured in 70 children, aged 11 days to 15 years. Cerebral av differences were studied in approximately 50% of the subjects. Mean values were: CBF 0.65 ml X g‐1X min‐1, cerebral exchange in nmoles Xg‐1X min‐1: oxygen 1348, glucose 248, acetoacetate 12,3‐hydroxybutyrate 34 (uptake), lactate‐48, pyruvate‐8 (release). No net exchange of amino acids was found with the exception of histidine (uptake). Neither CBF nor the cerebral exchange of oxygen and circulating substrates showed any correlation to age within the group. Compared with adults anesthetized by the same technique (barbiturate induction, nitrous oxide‐oxygen relaxant) the children had a slightly higher mean CBF, while the cerebral up‐take of oxygen and glucose were equal to values in adults. The cerebral uptake of ketone bodies was higher in children than reported values in adults investigated in the awake state after compa

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07114.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Hanson, E., Eriksson, B. O. and Bake, B. (Department of Paediatric Surgery, Department of Paediatrics and Department of Clinical Physiology, University of Göteborg, Göteborg, Sweden). Lung volumes and pulmonary gas exchange after coarctectomy. Acta Paediatr Scand, 69:467, 1980.—Ventilatory lung function and pulmonary gas exchange were assessed during rest and exercise up to the maximal level in nineteen males aged 16–28 years, eleven years after surgery for coarctation of the aorta. Compared to the normal Swedish standards, the lung volumes indicated a restrictive impairment of lung function. However, the age range in this series of patients is outside the age range of reference values for both children and adults. When the effect of age on the lung volumes was allowed for they were found to be less restrictive. Pulmonary gas exchange was normal at rest and during maximal exercise. Thus, the aortic malformation and the thoracotomy did not teed to any marked impairment of lung fun

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07115.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Tal, Y., Crichton, J. U., Dunn, H. G. and Dolman, C. L. (Department of Paediatrics, University of British Columbia, Vancouver, B.C., Canada). Spinal cord damage: a rare complication of purulent meningits. Acta Paediatr Scand, 69:471, 1980.—Three cases of spinal cord damage following acute bacterial meningitis are described. Two children survived with neurological sequelae, while one died. Autopsy showed extensive spinal cord necrosis. The possible mechanisms for this rare complication are discussed and a possible connection with transient cardiorespiratory arrest is suggeste

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07116.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Pollak, A., Widhalm, K., Havelec, L., Frisch, H. and Schober, E. (Division of Neonatology and Congenital Disorders, Department of Paediatrics and Institute for Medical Statistics and Documentation, University of Vienna, Vienna, Austria). Glycosylated hemoglobin (HbA1c) and plasma lipoproteins in juvenile onset diabetes mellitus. Acta Paediatr Scand, 69:475, 1980.—Plasma lipid and lipoprotein levels and hemoglobin A1c. estimates of diabetic control were measured in 19 juvenile‐onset diabetics (8 girls and 11 boys) upon admission (day 1) and at the end (day 25) of a 4‐week summer camp, where the patients were put on a controlled diet with a daily linoleic acid intake of about 16 g. Lipoproteins were also measured in 64 healthy controls. When values on day 25 were compared with those of day one, a slight but significant decrease in mean hemoglobin Ate (10.4±0.3 vs. 9.8±0.4% of total Hb; M±S.E.M.;p<0.05) was noted, as well as an increase in mean high density lipoprotein cholesterol (1.0±0.07 vs. 1.3±0.1 mmol/l; M±S.E.M.;p<0.02) and a decrease in mean triglycerides (1.2±0.1 vs. 0.7±0.04 mmol/l; M±S.E.M.;p<0.001). A linear correlation was found between hemoglobin A1con day 25 and urine glucose excretion during the camping period (p<0.01). However, no relationship was noted between hemoglobin A1cand either lipids or lipoproteins. Other factors, e.g. the controlled intake of saturated fat or physical activity could have been responsible for the changes in triglycerides and high‐density lipoprotein cholesterol levels noted by th

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07117.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Vetter, U., Heinze, E., Beischer, W., Kohne, E., Kleihauer, E. and Teller, W. M. (Centers of Paediatrics and Internal Medicine, University of Ulm, FRG). Haemoglobin A1c: a predictor for the duration of the remission phase in juvenile insulin dependent diabetic patients. Acta Paediatr Scand, 69:481, 1980.—Increased HbA1cconcentrations in diabetic patients indicate retrospectively a poor metabolic control during the preceding 2–3 months. In the present study attempts have been made to use the HbA1cconcentration at the time of diagnosis as an indicator of the duration of the remission phase in 23 juvenile diabetic children. The regression analysis revealed a significant negative correlation between the initial HbA1cconcentrations and the duration of the remission phase defined as no glucose excretion, an insulin requirement of less than 0.5 U/kg/day and detectable serum C‐peptide concentration (r= ‐0.84,p<0.001). The results suggest that the initial HbA1cconcentration may serve as a useful indicator to predict the duration of the remission phase in juvenile‐onset diabeti

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1980.tb07118.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY