摘要:

The maternal and umbilical cord bilirubin concentration at delivery, a yellow skin colour on the first postnatal day, an increase in the yellow skin colour during the first 24 h of postnatal life, and carbon monoxide excretion are all associated with the later development of neonatal jaundice in the healthy, mature newborn infant. Based on the results from these methods, and especially when the results from two or more of the methods are combined, it is possible to define low‐ and high‐risk groups as far as subsequent jaundice is concerned. If jaundice develops, yellow skin colour measurements can often replace plasma bilirubin determinations. Dependent upon the local current consensus for bilirubin determinations, around 50% of plasma bilirubin determinations can be avoided. Recent research suggests that yellow skin colour measurements may provide information concerning the risk of bilirubin encephalopathy, in addition to their relation to the plasma bilirubin concentrat

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14046.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14047.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Book reviewed in this article:Ross EM, Woody RC.Baillière's Clinical Paediatrics— Epilepsy, vol. 2, no. 3. London: Baillière Tindall, 1

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14048.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14049.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14050.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

The correlation between lipoprotein(a) (Lp(a)) concentrations in children aged 7‐24 months and their family members was determined and the association between the Lp(a) values of the children and a family history of coronary heart disease (CHD) was assessed. The Lp(a) values of the children correlated strongly with midparent Lp(a) values as early as at 7 months of age (r= 0.54 to 0.59,p<0.0001). This correlation was stronger than the correlation of serum total cholesterol and total cholesterol corrected for Lp(a) ‐ cholesterol between children and parents. None of the parents had CHD. The median Lp(a) concentration of the parents with a family history of CHD was significantly higher than that of parents with no such history (111 vs 87 mg/l,p = 0.024). However. the children's Lp(a) levels were not associated with CHD in their grandparents. The genetic dependence of the Lp(a) concentration is already evident in infancy. The Lp(a) concentration in young parents, but not in their 24‐month‐old children, is associated with CHD in grandparents. This may be explained by a dilution of the genetic influence on Lp(a) over two gene

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14051.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

A total of 235 measurement points of 57 Dutch women with Turner's syndrome (TS), including women with spontaneous menarche and oestrogen treatment, served to develop a new Turner‐specific final height (FH) prediction method (PTS). Analogous to the Tanner and Whitehouse mark 2 method (TW) for normal children, smoothed regression coefficients are tabulated for PTS for height (H), chronological age (CA) and bone age (BA), both TW RUS and Greulich and Pyle (GP). Comparison between all methods on 40 measurement points of 21 Danish TS women showed small mean prediction errors (predicted minus observed FH) and corresponding standard deviation (ESD) of both PTSRUSand PTSGP, in particular at the “younger” ages. Comparison between existing methods on the Dutch data indicated a tendency to overpredict FH. Before the CA of 9 years the mean prediction errors of the Bayley and Pinneau and TW methods were markedly higher compared with the other methods. Overall, the simplest methods—projected height (PAH) and its modification (mPAH)—were remarkably good at most ages. Although the validity of PTSRUSand PTSGPremains to be tested below the age of 6 years, both gave small mean prediction errors and a high accuracy. FH prediction in TS is important in the consideration of growth‐promoting therapy or in the evaluation of

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14052.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

The aim of this open study was to observe linear growth in young children with asthma treated with nebulized budesonide. Infants and young children (<3 years old) with severe uncontrolled asthma were studied. They were treated with nebulized budesonide (1‐4mgday‐1) and treated for at least 6 months. Height standard deviation scores (HtSDS) were measured before (“pre‐measurements”) immediately prior to commencing nebulized budesonide therapy (baseline) and after at least 6 months of therapy (“post‐measurements”). The mean HtSDS score at pretreatment was ‐0.21 and at baseline had fallen further to ‐0.46. The mean HtSDS increased to ‐0.17 when the post‐measurements were made (p= 0.035) after at least 6 months of nebulized budesonide therapy. Treatment with nebulized budesonide for longer than 6 months in very young children with severe asthma was not associated wit

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14053.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Sustained attention was studied in 48 children with early treated congenital hypothyroidism and 35 healthy controls, using a computer‐paced and a self‐paced continuous performance task. The performance of the patients, particularly those in the low T4 group (38 patients with T4 levels<50 nmol/1 at neonatal screening), declined in the final stage of the computer‐paced task, suggesting a problem in remaining attentive over time. The performance of all children declined in the first and improved in the final stage of the self‐paced task. This pattern was most pronounced in the low T4 group, reflecting greater variability in their task performance over time, again indicating a problem in sustaining attention. No correlation was found between onset of treatment and sustained attention. The small size of the intermediate T4 group (10 patients with T4 levels ≥ 250 nmol/1 at neonatal screening) made the results more difficult to interpret and may have concealed a problem with sustained attention in t

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14054.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

During a 2 year period, 175 children below 6 years of age (median 0.4 year) with non‐obstructive symptomatic urinary tract infection were studied by99mTc dimercaptosuccinic acid (DMSA) scintigraphy. DMSA scintigraphy was performed at a median of 10 days after the start of treatment and was abnormal in 73 children (42%), equivocal in 29 (16%) and normal in 73 (42%). Reflux was seen in 27% of all children and in 38% of the renal units that were abnormal at DMSA scintigraphy. A decreasing frequency of abnormalities at DMSA scintigraphy was seen within the first 14 days after the start of treatment. C‐reactive protein and grade of reflux correlated significantly with abnormal DMSA studies. To demonstrate renal involvement in acute urinary tract infection, DMSA scintigraphy should be performed within days after the start of treatment. It is noteworthy that reflux was seen in less than half of renal units with abnormal DMSA scintigra

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1996.tb14055.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY