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1. |
Disaccharidases and Histology of Duodenal Mucosa in Congenital Lactose Malabsorption |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 257-263
KARI LAUNIALA,
PEKKA KUITUNEN,
J. K. VISAKORPI,
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摘要:
SummaryA study has been made of the disaccharidase activities and histology of duodenal mucosa in two infants with typical congenital lactose malabsorption. The mucosal samples were taken by means of peroral intestinal biopsy. At the time Of biopsy, the patients were 2½ and 4½ months old and they had been on lactose free diet 39 days and 3 ½ months respectively.Both patients demonstrated a typical clinical picture of lactose and cellobiose malabsorption. In the mucosal samples, lactase and cellobiase activities were almost absent in both patients, whereas other disaccharidase activities were within the normal range. The histological picture of the mucosa was normal in one patient, and slight, partial villous atrophy was seen in the other.This study confirms that the cause of congenital lactose malabsorbtion is an enzyme defect of the intestinal mucosa which histologically may appear norm
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17652.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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2. |
Vaccinia Gangrenosa with Normal Humoral AntibodiesA Case Possibly Due to Deficient Cellular Immunity Treated with N‐Methylisatin β‐Thiosemicarbazone(Compound 33T57, Marboran) |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 264-272
O. HANSSON,
S. G. O. JOHANSSON,
B. VAHLQUIST,
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摘要:
SummaryA case of vaccinia gangrenosa with normal antibodies and deficient cellular immunity against vaccinia‐antigen is presented. Administration of hyperimmune vaccinia1 gamma globulin failed to stop the progression of the disease. Treatment with Compound 33T57 was successfu
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17653.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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3. |
Respiratory Syncytial VirusAn Outbreak of Acute Respiratory Illnesses in a Home for Infants |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 273-279
GÖRAN STERNER,
SIGVARD WOLONTIS,
BJÖRN BLOTH,
GEORG DE HEVESY,
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摘要:
SummaryA report is given of an outbreak of acute respiratory illness in a home for infants in Stockholm.Respiratory syncytial (RX) viruswas recovered from nasopharyngeal and/or throat swabs from 13 out of 15 infants (1–13 months old). Complement fixation (CF) tests against RS antigen showed at least 4‐fold rises of antibody titre in 7 out of 15 paired sera, including sera from two infants, from whom no virus was isolated. There was no rise in CF antibody titre against adenovirus, influenza A and B, parainfluenza 1, 2 and 3, mumps or herpes simplex antigens. RS virus was recovered 2 days before the onset of illness as well as 9 days afterwards. The incubation period was estimated to be from 3 to 5 days.All infants living in the home fell ill during a period from April 4 to April 30, 1964. Two‐thirds of the infants had febrile nasopharyngitis with cough and one‐third had symptoms and signs from the lower parts of the respiratory tract. Two infants had bronchopneumonia and two others were critically ill in bronchiolitis. All infants s
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17654.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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4. |
Acute Respiratory Illness with Mycoplasma PneumoniaeAn Outbreak in a Home for Children |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 280-286
GÖRAN STERNER,
GEORG DE HEVESY,
GÖSTA TUNEVALL,
SIGVARD WOLONTIS,
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摘要:
SummaryAn outbreak of acute respiratory illness, in a few cases combined with primary atypical pneumonia (P.A.P.), occurred in August‐October 1964 in a home for children in Stockholm. Seventeen out of 22 children (age 1–12 years) fell ill during the observation period, four of them twice.By using a battery of antigens (viruses, Mycoplasma pneumoniae (MP) and bacterial antigens) in a serological study on paired sera, it was found that nine children developed a significant rise of CF antibodies against MP only, two had rise of antipneumolysin titre only, whereas one child had rising antibody titres against adenovirus and MP as well as against Haemophilus influenzae. MP was cultivated from the throat in four cases.Of the 15 children with proved or probable fresh MP infection two were healthy, four had an afebrile mild upper respiratory illness, six had acute respiratory illness with fever, mostly of short duration, and without clinical signs of pneumonia. In three cases, all above 5 years of age, P.A.P. was demonstra
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17655.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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5. |
Experiences with Human Growth Hormone in Pituitary Dwarfism |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 287-293
M. SEIP,
O. TRYGSTAD,
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摘要:
SummaryExperiences with HGH treatment of twelve hypopituitary dwarfs for periods varying from 6 to 41 months are reported.All the patients were considered to have hypopituitarism from birth, four of them of the hereditary type, four possibly due to traumatic birth or neonatal asphyxia, and four from an unknown cause. In six patients detailed information concerning growth during the first year of life could be obtained. All of these patients had a degree of growth retardation before one year of age. We consider this to be the rule rather than the exception in pituitary dwarfism.The most important diagnostic evidence was a marked degree of growth retardation accompanied by a pronounced delay in skeletal maturation, and, in most cases, signs of secondary hypothyroidism, increased insulin sensitivity, and a poor response to metopirone administration. None of the patients who had passed the normal age of puberty had matured sexually.All twelve patients responded well to HGH therapy. During the first year of treatment the average height increment was 10 cm (“catch‐up” growth). With continued treatment a normal rate of growth, about 6 cm/year, was obtained. There was no disproportionate acceleration of skeletal maturation in any of the patients. None of them has so far become resistant to HGH administration. The oldest patient has reached normal height. Whether this will be possible not only in the moderately severe, but also in the most severe cases of pituitary dwarfism, can not yet be stated.The possibility of using human gonadotrophic hormones in an attempt to produce sexual maturation in these patients is discussed br
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17656.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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6. |
The Oxygen Cost of Minor Changes in Heat Balance of Small Newborn Infants |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 294-300
WILLIAM A. SILVERMAN,
JOHN C. SINCLAIR,
F. J. AGATE,
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摘要:
SummaryMeasurements of gaseous metabolism small newborn infants whose anterior abdominal skin temperatures were stabilized at fixed levels (35, 36 and 37°C) for 15 to 25 hours revealed that mean oxygen consumption was lowest in the 36°C condition. From the oxygen cost of small departures in heat balance it is suggested that a “neutral thermal state” small neonates may be achieved when environmental conditions are adjusted to maintain the abdominal skin temperature between 36 and 37°C. The deep body temperature in the “neutral thermal state” is lower in these very small babies than is generally considered to be a normal deep body temperature in human subjects.The relationship between temperature and metabolism in undergrown as compared with normally grown infants should be investigat
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17657.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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7. |
Antibody Response after Immunisation with Typhoid‐Paratyphoid A and B Vaccine in Kala‐azar |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 301-304
CHRISTOS CASSIMOS,
STELLIOS LAZANAKIS,
THEODORE THOMAIDIS,
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摘要:
SummaryThe ability to produce antibodies during the course of Kala‐azar was studied by immunising 12 Kala‐azar patients with T.A.B. raccine and 12 controls. Controls yielded good antibody response after immunisation while patients with Kala‐azar yielded poor antibody response. The etiology of this deficiency is disc
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17658.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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8. |
Pulmonary Arterial Pressures of Newborn Infants Born with Early and Late Clamping of the Cord1 |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 305-315
RENÉ A. ARCILLA,
WILLIAM OH,
JOHN LIND,
IRA H. GESSNER,
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摘要:
SummaryHemodynamic studies were conducted on 32 normal, full‐term newborn infants, age 29 minutes to 11 hours, to determine the effect of placental transfusion upon the pulmonary circulatory adjustments after birth. In 10 infants, clamping of the cord was accomplished within 2 to 10 seconds after the delivery (earlyclamping), and in the other 22 infants it was done after cessation of the umbilical arterial pulsations (lateclamping).For comparative purposes, the pulmonary arterial pressures were related to the corresponding aortic pressure in the form of a P/A mean pressure ratio, and these were correlated with age in the 2 groups of subjects. The observed pulmonary arterial pressures in the 2 groups differed significantly. During the first 9 hours, the pulmonary pressures of the late‐clamped infants were approximately 90 % that of the aortic. In contrast, those of the early‐clamped infants were as low as 70 % of the aortic pressures by the second hour, and nearly 50 % by the fourth hour.A hypothesis is presented that the higher pulmonary arterial pressures in the late‐clamped infants is due to greater pulmonary vasoconstriction resulting from greater pulmonary capillary…venous filling…a consequence of the large blood volume following maximal placental
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17659.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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9. |
Incidence In infants and Mortality from Congenital Malformations of the Circulatory System |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 316-320
K. F. KERREBIJN,
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摘要:
SummaryThis study comprises an investigation into the incidence of congenital malformations of the circulatory system in all live births in 1958 among the inhabitants of the municipality of Leiden, and an analysis of the figures concerning congenital malformations of the circulatory system as an underlying cause of death in the Netherlands in the years 1951–1962.In 15 of 1817 children (8%) a congenital malformation of the circulatory system was found. A discussion is included of possible sources of error in the calculation of the incidence reported.The results can be considered as representative for the Netherlands as a whole. This means that the number of infants born alive in this country with a congenital malformation of the circulatory system will currently be about 2000 annually.Up to the present there has not been a decline in mortality figures for congenital malformations of the circulatory system in the Netherlands. Mortality ensues in 80 % of the cases in infancy. The number of infants dying from congenital malformations of the circulatory system is at the moment about 500 annually. One third die in the first week of life, half within the first mont
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17660.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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10. |
Generalized Histiocytic Reticulo‐Endotheliosis and Leuco‐Encephalopathy in Childhood |
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Acta Pædiatrica,
Volume 55,
Issue 3,
1966,
Page 321-328
KRISTER KRISTENSSON,
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摘要:
SummaryA report is given of a 6‐year‐old boy, who at 3 years of age suddenly developed signs of ataxia. Multiple eosinophilic granulomata of the bones were found, which healed on X‐ray treatment. Later a spastic tetraparesis and some epileptic fits complicated the picture. At autopsy a multifocal demyelinating leuco‐encephalopathy, histiocytic granulomata of the lungs and a diffuse histiocytic proliferation of the liver, spleen and thymus were found. Since a few cases of a similar demyelinating leuco‐encephalopathy hare been described in combination with HandSchüller‐Christian disease, a clinical variant of histiocytic reticulo‐endotheliosis, this combination must be more than a coincidence and has to be taken into consideration when a patient with histiocytic reticulo‐endotheliosis develops c
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1966.tb17661.x
出版商:Blackwell Publishing Ltd
年代:1966
数据来源: WILEY
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