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1. |
IMMUNOFLUORESCENT AND MORPHOLOGICAL STUDIES IN CONGENITAL NEPHROTIC SYNDROME1 |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 253-263
JUHANI RAPOLA,
ERKKI SAVILAHTI,
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摘要:
SummaryTwo kidneys from patients with congenital nephrotic syndrome obtained at nephrectomy at the age of 3 and 23 months, were investigated for possible immunopathological mechanisms for the kidney injury. Immuno‐fluorescent staining with anti IgG, IgM, IgA and /SIC‐globulins did not show attachment of immunolglobulins or complement to the glomeruli. Staining was found in some tubular casts and occasionally in tubular epithelium, as well. Electron microscopic studies of the glomeruli corroborated the idea that immunocomplexes are not conglomerated in the glomeruli because of the absence of typical deposits, which are usually found in association with positive immunofluorescent staining in various glomerulonephritides.Kidneys were also eluted with acidic buffer in order to remove antibodies from immunocomplexes. The eluates were analyzed for their immunoglobulin content and used for indirect immunofluorescent staining. The content of IgG of the kidney eluates was low and no difference of eluted IgG between the nephrotic kidneys and the control was apparent. No binding of immunoglobulin with structures of normal kidney could be seen in the indirect immunofluorescent study.Our results corroborate the previous results (10) that immunopathogenesis is not essential in the congenital nephrotic syndr
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06654.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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2. |
HYPOSENSITIZATION IN HOUSE DUST ALLERGY ASTHMA |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 264-268
KJELL AAS,
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摘要:
SummaryA double‐blind controlled study of the effect of house dust hyposensitization was conducted in 93 patients allergic to house dust. The allergy diagnosis was established by bronchial provocation tests, and the degree of bronchial sensitivity to house dust extracts (bronchial threshold dose for allergen) was assessed before and after 2 1/2–3 years' injection treatment.The specific hyposensitization with two different house dust extracts was superior to placebo injecti
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06655.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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3. |
PROTHROMBIN IN NEWBORNS AND DURING THE FIRST YEAR OF LIFE |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 269-277
I. NOREN,
E. CARLSSON,
G. KRETZSCHMAR,
A.‐C. TEGER‐NILSSON,
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摘要:
SummaryProthrombin concentration, determined specifically with a new two‐stage method, was compared with thrombotest activity in samples from infants, aged 0–21 days. There was a significant correlation between the two methods.Effect of treatment with vitamin K and plasma was registered with both methods.As the distribution of prothrombin and thrombotest values from normal, full‐term neonates was slightly skew, mean value and S.D. was calculated from the logarithmic values. The normal range, expressed as mean ± 2 S.D. was for prothrombin 26–85 % and for thrombotest 27–74% (values corrected for hematocrit).No bleeding was observed in any patient with prothrombin above 20% and thrombotest above 22% (corrected values). Most low values in newborns were found in children suffering from hypoxia.Prothrombin concentration was also compared with prothrombin‐proconvertin activity in samples from children, aged 0–12 months. In the healthy child prothrombin values reached the normal adult level at the age of 6–12 months, prothrombin‐proconvertin values at the age
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06656.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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4. |
CIRCULATORY ADAPTATION IN THE THERMOREGULATION OF FULLTERM AND PREMATURE NEWBORN INFANTS |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 278-284
KRISTINA BERG,
OLOV CELANDER,
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摘要:
SummaryBlood flow measurements by venous occlusion plethysmography were performed on 131 sleeping healthy fullterm newborns at various external temperature conditions. The peripheral circulation varies among different individuals, but a definite relationship between ambient temperature and the rate of peripheral circulation could, nevertheless, be established.Different series of observations on exposure to acute changes of temperature conditions on a further 46 newborn infants allow the following conclusions:The control of peripheral circulation in relation to the temperature of the surroundings is reflex in nature and independent of the local effects of a cold stimulus.Circulatory changes are quantitatively prominent and do not support the view that thermolability in the newborn is due to a deficient thermocontrol of the cutaneous circulation.The circulatory thermoreflex operates even during the first day of life and is as prominent in premature infants as in fullterm infants.The importance of these observations in relation to other mechanisms deciding heat loss and thermogenesis in the newborn is briefly discussed.
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06657.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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5. |
NIEMANN‐PICK DISEASE AND GIANT CELL TRANSFORMATION OF THE LIVER |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 285-294
A. ASHKENAZI,
R. YAROM,
A. GUTMAN,
A. ABRAHAMOV,
A. RUSSELL,
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摘要:
SummaryThis report presents three siblings with neonatal jaundice who died before the age of three months. They were shown on autopsy to be suffering from Niemann‐Pick disease together with a giant cell transformation of the liver.The resemblance of these cases to previously reported examples of the above mentioned double condition is stressed, and a suggestion is made that this variant of the Niemann‐Pick disease presents a special genotypic syndrome within the group with the biochemical disorder broadly classified as sphingomyelin lipido
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06658.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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6. |
CARDIOMEGALY IN ASSOCIATION WITH NEONATAL HYPOGLYCAEMIA |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 295-298
M. McC. REID,
B. J. REILLY,
A. I. MURDOCK,
P. R. SWYER,
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摘要:
SummaryFifty‐two infants with hypoglycaemia were seen over a 12 month period. Six of these infants had cardiac enlargement with signs of failure and pulmonary oedema in association with isolated hypoglycaemia. Signs and symptoms suggestive of cardiac failure corresponded to the period of hypoglycaemia and disappeared when blood sugar levels were raised by appropriate treatmen
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06659.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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7. |
URINARY GLYCOSAMINOGLYCAN EXCRETION IN THE NEONATAL PERIOD |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 299-300
C. A. PENNOCK,
B. A. WHARTON,
FRANCES WHITE,
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摘要:
SummaryUrinary glycosaminoglycan excretion relative to creatinine is high during the neonatal period reaching a peak in the second week of life and thereafter declining throughout childhood. The difficulty in early diagnosis of the mucopolysaccharidoses during the neonatal period is emphasized.
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06660.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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8. |
INHIBITION OF ERYTHROPOIESIS BY PLASMA FROM NEWBORN INFANTS |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 301-308
PEER SKJÆLAAEN,
SVERRE HALVORSEN,
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摘要:
SummaryThe marked and rapid decrease of erythropoie‐sis in the normal newborn infants may be due to disappearance of erythropoietin alone, but an inhibitory mechanism may also be involved. Several authors have previously reported the presence of erythropoiesis‐inhibiting factors in plasma from high altitude natives brought to sea level and in plasma from hypertransfused animals. The present studies of59Fe incorporation in RBC of polycythemic mice injected with plasma from normal and hyperbilirubinemic newborn infants, show that erythropoietic in‐hibitor(s) is present in the plasma of infants at least from the fourth day of life. This inhibition was not due to the bilirubin content. A possible influence of estrogen was discussed and found to be unlikely. The relation to chalones, the tissue specific inhibitors of mitosis, is disc
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06661.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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9. |
FAILURE TO THRIVE IN LEBANON I. EXPERIENCE WITH SOME SIMPLE SOMATIC MEASUREMENTS |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 309-316
ABDALLAH A. KANAWATI,
DONALD S. McLAREN,
ISABELLE ABU‐JAWDEH,
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摘要:
SummaryDuring a period of 12 months 1 231 Lebanese Arab children of low socio‐economic class, 3–48 months of age living in three locations were measured. The measurements were weight, height, head circumference and mid‐arm circumference. The results were expressed as percentage of international standards for boys and girls separately. The patterns of deviation from the standard values varied according to the measurement. In general for both sexes there was a falling off between 6 and 18 months, greatest for weight and mid‐arm circumference with some recovery later, and less for height and head circumference without recovery later. The possible influences of location and season of observation and birth were studied. Using these four somatic measurements an Index of Thriving was developed for the subsequent study of contrasting groups of “control” and “failure to thrive” children. The use of this and other simple means of assessing failure to thrive in the fie
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06662.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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10. |
POSTNATAL CHANGES IN SOME RED CELL PARAMETERS |
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Acta Pædiatrica,
Volume 60,
Issue 3,
1971,
Page 317-323
Y. MATOTH,
R. ZAIZOV,
I. VARSANO,
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摘要:
SummaryThe red blood picture was studied in detail from birth to 12 weeks. The low point in the red cell count was reached in the seventh week, which represented the turning point from a negative to a positive balance between cell production and destruction. From the dynamics of the total number of circulating red cells it was concluded that, although erythropoiesis slows down after birth, a considerable amount of red cell production takes place during the first few postnatal weeks.The MCHC increased significantly over the first 5–6 postnatal weeks and remained constant thereafter.Macrocytes predominated at birth. Their percentage distribution decreased after the second week with a corresponding increase in microcytes.The red cell density distribution curve in the neonatal period is sigmoid in shape. The range of densities is, however, wider than in the adult. The curve shifts gradually to the heavy side from birth to 5 weeks, while from 5 to 12 weeks a shift back to the light side is observed. Macrocytes preponderate in the light fraction
ISSN:0803-5253
DOI:10.1111/j.1651-2227.1971.tb06663.x
出版商:Blackwell Publishing Ltd
年代:1971
数据来源: WILEY
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