摘要:

SummaryActinomycin D in a dose of 15 µg per kilogram body weight per day for 5 days was given at intervals of two months for two years in the treatment of Wilms' tumor. It was observed that each course of actinomycin D therapy resulted in the occurrence of transverse lines of increased density at the terminal segments of growing bones. Linear growth proceeded at the expected rate in all children studied. Evidently, arrest of longitudinal growth is no prerequisite for the development of transverse lines, and even the formation of multiple lines within a relatively short period does not necessarily imply any retardation of linear growth. The formation of transverse lines in response to actinomycin D administration may indicate that interference with growth hormone secretion and/or peripheral action may be involved in the development of these lines

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06963.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryNerve‐excitability measurements performed early in the course of the disease are of a good prognostic value. The results show that when excitability is maintained unimpaired after 72 hours of the onset, there is a chance of 100% spontaneous cure. When the excitability is diminished by less than 50%, 90% recovery may occur, but when it is markedly diminished or absent the prognosis is bad.The schedule of treatment to be followed should be based on the result of nerve excitability measurement early in the course of the disease.Systemic vasodilators, as nicotinic acid early in the course of the disease has excellent effect as it cuts the vicious circle of arteriolar spasm without increasing pressure within the facial canal.It is advisable that early short wave therapy should be avoided as it may increase nerve compression through local vascular congestion in the vicinity of the nerve.Incidence of physiological block is higher in children with Bell's palsy than in corresponding adult patients who, as a result have a higher incidence of nerve degeneration and worse prognosis.The severity of paralysis does not indicate the degree of nerve lesio

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06964.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

Summary60 cases of cryptorchidism and 5 intersexes were examined with andrography (pneumo‐pelvigraphy). Of these, 36 were operated upon.The roentgen findings are compared with the palpatory and surgical findings. The value of the method is discussed and the indications for it are give

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06965.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryIn 43 children with idiopathic nephrotic syndrome (INS) who were treated with ACTH or corticosteroids, the evolution was studied after 4 to 14 ½ years. Frequent control investigations revealed that 29 patients were probably cured, 3 were dead, 2 showed a late recurrence and in 1 sequelae were found. In 7 patients, the NS was characterized by the occurrence of multiple relapses.The comparison of these data with those of a prior identical follow‐up study in 44 patients of the pre‐hormonal era, permitted a gross evaluation of the influence of hormone therapy on the natural course of the INS.It was demonstrated that more hormonally treated patients cured, but that, due to the more frequent occurrence of relapses, definitive healing was significantly postponed. Less patients died, the number of late relapses and sequelae was not very different in both groups. Multiple relapses were seen only in the hormonal group. The cured patients and those with multiple relapses thus probably represent the patients who would have died in the pre‐hormonal era, but it is not known which effect is due to antibiotics and hormones respectively.The long‐term effect of hormone therapy will depend on the evolution in this group with multiple relapses. The histologic lesions in the kidney, found in some of these patients suggest that probably in a part of them, a fatal issue is to be expected. Further follow‐up studies in the other patients with multiple relapses but with shorter follow‐up periods, will reveal if identical lesions occur later in all these patients. If this is the case, the long‐term effect of hormone therapy in our patients consisted in an important postponement of t

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06966.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryA modification of the open circuit CO‐method was developed for determination of the total amount of haemoglobin in newborn infants. Simultaneous determinations of the COHb level, the pulmonary CO elimination and the total haemoglobin were performed on 32 full‐term newborn infants. The rate of haemoglobin catabolism was calculated from the CO elimination and the total haemoglobin on the assumption that CO is formed mainly from degraded haemoglobin and is eliminated quantitatively in the expired air.An evaluation of the COHb level as a quantitative measure of haemolysis was m

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06967.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryA case report is presented of a 6‐year‐old girl with a severe progressive encephalopathy of late infantile onset and with changes indicating marked disturbances in the metabolism of linolenic a

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06968.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryThe concentration of plasminogen activator in the various organs of the human genito‐urinary tract and in the adrenals was investigated in 15 fetuses (aged 15 to 24 weeks of pregnancy) and in 7 premature or still‐born infants (aged 26 to 38 wee

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06969.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryAn infant presented at three months with intolerance of glucose, galactose and fructose. It was thought that this was possibly secondary to staphylococcal infection. Recovery of monosaccharide intolerance coincided with recovery from infection. The infant was treated with a sugar‐free diet which is described in detail. It is important to detect and correct ketosis and/or hypoglycaemia at an early stage when such a diet is use

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06970.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryWith the technique of scalp capillary blood sampling, the blood glucose levels of human fetuses were studied in normal cases as well as in cases with toxemia, Rh‐immunization or prolonged pregnancy. Before the onset of labor the mean level was 61.5 mg/100 ml, and an increase was demonstrated as labor progressed. The maternal concentration was always somewhat higher than that in the fetus, and an analogous increase was observed during labor. No significant differences could be demonstrated between the normal and abnormal cases, either prior to or during labo

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06971.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY

摘要:

SummaryTwo or more serial blood glucose determinations were performed before the age of five days in 964 neonates treated in the Children's Hospital. Two or more values of 20 mg/100 ml or less, considered to indicate significant hypoglycemia, were observed in 55 infants, or 5.7% of those studied. The incidence of significant hypoglycemia was 20% in dysmature infants, 16% in infants of diabetic mothers and 15% in critically ill infants dying within ten days of birth. No other important predisposing factors were detected. A screening procedure for the early diagnosis of neonatal hypoglycemia is described.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1968.tb06972.x

出版商:Blackwell Publishing Ltd    

年代:1968

数据来源: WILEY