摘要:

Abstract.Fifty‐one children surviving IRDS with CPAP alone or CPAP and IPPV were studied at the age of 2.5 to 4.0 years. One child had developed tetraplegia and mental retardation and 6 children were speech‐retarded. Correlation with perinatal events showed that this group of children had a significantly lower gestational age and birth weight, a lower Apgar score and a higher Pço2prior to ventilatory treatment than the remainder. Re‐examination by age 4.0 to 5.0 years showed persistent handicaps in only four of the seven ch

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04980.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.A three‐generation transmission of under five percentile values for serum low density lipoprotein and low density lipoprotein cholesterol typical of heterozygous familial hypobetalipoproteinemia was demonstrated in a Danish family. Slight clinical signs of CNS abnormality were found in 4 of the 8 subjects with heterozygous familial hypobetalipoproteinemia, but did not resemble the neurological findings in abetalipoproteinemia nor in the previously described patients with familial hypobetalipoproteinemia. There were no signs of myelin dysfunction in the central nervous system as judged from the normal latency of visual and somatosensory evoked potential

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04981.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.S‐IgA antibodies against cholera toxin and rotavirus were assayed in 43 colostral samples by means of an enzyme‐linked immunosorbent assay (ELISA). All specimens contained specific S‐IgA antibodies against both antigens. Significant antibody titres to the antigens were demonstrated in almost all colostral sa

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04982.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Early infant feeding habits, current dietary intake and serum lipids were investigated in 31 infants, age 6–10 months and 64 children, age 3–4 years. In the infants there was a correlation between serum lipid levels and the amount of saturated fat and the P/S ratio of the diet. No such correlation was found in the 3–4 year old children. Neither was there any correlation between the type and duration of early infant feeding and subsequent serum lipid levels. In both the infants and the 3–4 year old children serum cholesterol concentration correlated with the serum cholesterol concentration in each of the

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04983.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The peak rise in breath hydrogen and the volume of excess pulmonary excretion of hydrogen in response to a 10 g dose of the non‐absorbable disaccharide, lactulose, was significantly lower in children with active gastroenteritis and diarrhea than in non‐diarrheal controls. Thus, despite the fact that the H2breath test is a convenient, noninvasive technology for use in children, it cannot be recommended for measuring carbohydrate malabsorption in individuals with active, on‐going episodes of dia

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04984.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Renal function was studied in three patients with post‐streptococcal, four patients with IgA and one patient with non‐streptococcal proliferative glomerulonephritis (GN) at the onset of the disease and two, six and 12 months later. Renal biopsies were performed at the onset of the disease and 12 months later. Standard clearance techniques were used for the functional studies. The latter were performed during hydropenia and continuous isotonic saline infusion. During hydropenia, the GFR was uniformly depressed shortly after the onset of the disease, but it normalized during the following two months. The filtration fraction was depressed in poststreptococcal GN at the onset and it normalized with the GFR. In IgA GN, the filtration fraction remained within normal limits during the entire course of the illness. The natriuretic response to isotonic saline volume expansion was low in all patients at the onset of the disease, but normalized in post‐streptococcal and IgA GN during the one‐year follow‐up. In spite of normalized renal function, biopsy findings in IgA GN were unchanged 12 months later. An episode of macroscopic hematuria in one patient with IgA GN at the six‐month investigation had no apparent effect on ren

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04985.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Structural and functional alterations in duodenal mucosa from 17 children with rotavirus enteritis were assessed. Structural changes were found in specimens from all patients. Patients with the most severe mucosal damage were more likely to require intravenous therapy to correct dehydration. Depression of one or more mucosal disaccharidases was found in 14 of 16 patients. Repeat duodenal biopsy three to eight weeks later in six patients showed marked improvement. The study clearly shows that rotavirus can cause a marked structural and functional lesion in the upper small intestine which is rapidly reversible.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04986.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.A patient is described with a monoclonal immunoglobulin of the IgG class in the serum and no detectable IgM and IgA. Extensive immunological investigations showed the absence of B‐lymphocytes in bone marrow and peripheral blood. Moreover, plasma cells were not present in the bone marrow. The monoclonal IgG was synthesized in the gastrointestinal tract. The cellular immune‐status of the patient was normal. Clinically the patient suffered from gastrointestinal and severe respiratory tract infections. It was concluded that the findings are consistent with the diagnosis congenital agammaglobulinaemia with concurrence of monoclonal IgG. It was postulated that the cell clone in the gastrointestinal tract resulted from an escape of a pre‐B cell clone from the recognized arrest of pre‐B cells in congenital agammaglobul

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04987.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.A retrospective analysis was performed on 164 children and adolescents with persistent hypertension. Among the un‐selected 115 patients with hypertension seen within the last three years 47 (41%) exhibited renal disease, 37 (32%) coarctation of the aorta, 10 (9%) miscellaneous associated causes and 21 (18%) no associated cause (essential hypertension). A substantial number, 53/164, had a primary disease potentially curable by surgery, and in 37 patients the blood pressure was normalized postoperatively. The outcome depended mostly on the basic disease and the availability of chronic hemodialysis. 11/164 children have died, all because of terminal basic disease, and one with simultaneous hypertensive crisis. We thus recommend a thorough investigation in the case of a child with persistent hypertensio

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04988.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The concentration of tryptophan and the degree of binding of the amino acid to protein were examined in human plasma during the perinatal period. Both total and unbound (free) tryptophan were higher in cord vein plasma than in the maternal circulation, the concentration gradient being approximately 1: 2. The proportion of the total plasma tryptophan concentration that was not bound to protein was less in cord vein plasma than in the maternal circulation. After birth the proportion in infant plasma fell significantly. Both total and free tryptophan fell during the first 24 hours of postnatal life. Total tryptophan returned to the cord vein plasma level 6–8 days after birth whilst free tryptophan failed to increase during the period of the observations. In premature infants total and free tryptophan also declined in concentration 12–24 hours after birth, suggesting the phenomenon to be related to birth rather than to gestational age. Phenylalanine remained unchanged whilst tyrosine increased in concentration during the first 80 hours of postnatal life. Thus, the availability of tryptophan to the tissues appears to decline during the immediate postnatal period and the results suggest that the requirement for tryptophan during this time may exceed the supply from standard artifical milk preparati

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1979.tb04989.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY