摘要:

SummaryTwo brothers are reported, who at the ages of two and three weeks respectively, demonstrated generalized tetanic convulsions. In both cases, hypocalcemia and hypophosphatemia were found. The serum magnesium of the elder brother was not determined, whereas the younger was found to have severe hypomag‐nesemia. Calcium administration had no effect on the condition of the elder one, who died at the age of 50 days. In the younger, magnesium alone led to a normalization of the clinical as well as the biochemical picture. On daily oral magnesium supplementation, the child is healthy and is developing normally.Data are presented which indicate that the hypomagnesemia is due to a selective defect in the absorption of this ion. The low serum calcium appears to be secondary to a magnesium deficiency.Morphological findings in autopsy and biopsy material are presented, demonstrating histological and electron microscopical changes most marked in the liver.On the basis of a familial occurrence of this disease, a hereditary genesis is considered likel

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04743.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryThree cases of trisomy 17–18 associated with oesophageal atresia and tracheo‐oesophageal fistula are described, and the clinical features of two other cases of trisomy 17–18 are summarised. It is concluded that the association between the two conditions is not so rare as previous reports su

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04744.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryEighteen newborn infants, 11 males and 7 females, with hypoglycemia, i.e. with blood glucose concentration of less than 20 mg per 100 ml were studied. Twelve infants were diagnosed as cases of symptomatic and 6 as cases of asymptomatic hypoglycemia. All infants with asymptomatic hypoglycemia were small for gestational age, whereas the symptomatic group was heterogenous from a clinical point of view.The disappearance rate of intravenously administered glucose (kG‐value) was studied before any treatment was started. The kG‐values were high in all infants with symptomatic hypoglycemia, in 10 exceeding +2 s.D. for normal infants of the same age. The symptomatic infants were treated with hydrocortisone or human growth hormone in addition to continuous glucose infusion. After the institution of therapy there was a rapid normalization of the kG‐values. The 6 infants with asymptomatic hypoglycemia had normal kG;‐values. They were only given a high caloric supply by means of breast milk. In two infants with symptomatic hypoglycemia repeated simultaneous determinations of kG‐values and the plasma concentration of free fatty acids revealed no relationship.At follow‐up examinations at ages from 5 months to 2 years, 2 out of the 12 infants in the symptomatic group were found to have severe cerebral damage. All infants with asymptomatic hypoglycemia were completely normal.The findings seem to have some clinical applications. Determination of the disappearance rate of intravenously administered glucose, primarily given as a diagnostic test, may differentiate between symptomatic and asymptomatic hypoglycemia. If in a doubtful case the kG‐value is normal, the likely diagnosis is asymptomatic hypoglycemia. In cases of symptomatic neonatal hypoglycemia repeated determinations of the kG‐value may provide a sensitive guide as to the effe

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04745.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryIn a series of 103 consecutive cases of severe cardiac disease in infants the diagnostic value of clinical examination, electrocardiogram and conventional roentgen examination was found to be very limited. Emergency use of cardiac catheterization and angiocardiography is necessary to achieve a correct diagnosis in these patients.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04746.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryA work test on a bicycle ergometer was carried out on 82 Swedish boys aged 15 to 19. The heart rates were recorded, both at the submaximal loads of 600 and 900 kpm/min and at the maximal work load. Maximal aerobic power was predicted from submaximal work loads and maximal heart rate. The heart rates obtained show decreasing values with increasing age at a given work load. This is partly ascribed to physical growth, and partly to some training effect noticeable in the older boys who have completed one year of building apprenticeship.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04747.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryTwo girls with Cornelia de Lange Syndrome, dying at the age of 4 weeks and 9 months respectively, are described.Published examples where necropsy was performed are reviewed and the congenital anomalies of internal organs are summarised.Although some neuropathological features probably result from arrest or retardation of maturation, there was evidence in the younger infant of associated breakdown of myelin.Morphological changes of pituitary, thyroid and adrenal glands, are frequent but no link with hypothalamic lesions has been found.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04748.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryBlood glucose, plasma insulin, FFA and β‐hydroxybutyrate values during intravenous glucose tolerance were reported in 20 small for gestational age (SGA) and 15 appropriate for gestational age (AGA) low birthweight infants. The babies were divided into three groups according to their age when tested;48 hours.Both the SGA and AGA infants cleared glucose more rapidly with increasing age. The change was more marked in the SGA babies. The clearance rates were similar to those reported in normal full‐sized infants.The insulin values before the glucose load were similar in all groups and comparable to those reported in normal newborn infants.The insulin response to glucose was variable. There were no significant differences with increasing age or between the two groups of infants. The insulin curve of the individual infant followed one of three patterns. Most commonly seen was a double‐peak curve. The infants who showed a single‐peak insulin response had a better but not significantly different glucose tolerance than that of the other babies. Infants with no appreciable insulin response still removed glucose from plasma at a rate similar to those with a double‐peak insulin curve. It is concluded that insulin as measured in peripheral plasma could not explain the rate of removal of glucose from the plasma of the newborn low birthweight infant.Infants of low birthweight had higher plasma FFA values as compared to that reported in normal full term infants. The FFA values in SGA infants were higher than those in AGA babies. In both groups of infants, the jS‐hydroxybutyrate values were comparable to those reported in normal full‐term babies. Thus there was an unexpected discrepancy between the high FFA and relatively low β‐hydroxybutyrate levels in plasma. The fall in plasma FFA and β‐hydroxybutyrate after glucose was minimal but similar in both groups of infants.The findings are compatible with a decreased sensitivity to insulin

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04749.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryThe effect of exchange transfusion in the electrolyte and acid‐base balance has been studied in 37 newborn infants undergoing the procedure because of hyperbilirubinemia. Particular interest was focused on possible relationships between induced changes and various pertinent parameters such as infant and donor blood characteristics and rate and volume of the exchange. A statistically highly significant decrease in pH and plasma bicarbonate was noted together with a decrease of the potassium level. Changes in other electrolytes were inconsistent. There was a highly significant correlation between rate of exchange and acid‐base disturbance as well as between induced potassium decrease and the total volume of the procedure. There was no demonstrable increase of the susceptibility to induced changes among the low‐weight infants. A recovery period of 20 minutes was usually sufficient to allow for the control of the metabolic derangement and in some instances an alkalotic overshoot was encountered as related to the preoperative control value. The potassium level continued to fall during the recovery period.The technical aspects of the procedure are discussed against the reported fin

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04750.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryThe plasma aminograms of mother's and cord vein plasma during delivery were studied in selected cases from a lower socio‐economi‐cal group in West Pakistan with a high incidence of intrauterine growth retardation of the foetus.There was a highly significant increase in the levels of the non‐essential amino acids glycine and ornithine in the mother's plasma and of glycine and proline in cord plasma. The plasma glycine/valine quotient was significantly increased in maternal as well as in cord plasma.It is suggested that the plasma glycine/valine quotient may serve as an index of subclinical protein undernutrition (low intake of dietary nitrogen) of mother and foetus and thus become a tool in the investigation of the immediate and late effects of this condition during pregnancy in human populations. The maternal quotient is not changed by short gestation or hypertensive disorder during preg

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04751.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY

摘要:

SummaryThe presence of precipitating antibodies toE. coliO antigens in consecutive serum samples from infants and children with pyelonephritis without obstructions in the urinary tract was studied using an immunodiffusion method. Precipitating antibodies were found in only five of 20 patients clinically diagnosed as having their first attack of pyelonephritis, but in all of 13 patients with a recurrent infection. Such antibodies were not found in any of 93 controls without symptoms or signs of urinary tract infection.The reason for the appearance of IgG precipitins toE. colimainly in patients with recurrent pyelonephritis is discussed with regard to three possibilities: a secondary antibody response induced by the recurrent infection, an adjuvant effect of endotoxin remaining from an earlier infection and finally more severe infections causing stronger antigenic stimuli in patients with tendency toward recurrencies.The detection of precipitating antibodies toE. coliO antigens might be useful for early recognition of patients with recurrent pyelonephritis, who are at risk to develop progressive renal scarring.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1969.tb04752.x

出版商:Blackwell Publishing Ltd    

年代:1969

数据来源: WILEY