ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12566.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12567.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

To evaluate the influence of dietary taurine supplementation on vitamin D absorption, we studied three groups of infants: 21 (11 preterm) were fed a taurine‐free formula, 21 (10 preterm) were fed a taurine‐supplemented formula (50 mg/100 g of powder) and 20 (9 preterm) were fed human, not heat‐treated milk. Taurine, total bile acids, glyco‐(GBA) and tauro‐(TBA) conjugated bile acids, 25–hydroxyvita‐min D3 (250HD3) and 1,25–dihydroxyvitamin D3 (1,250H2D3) were determined in all infants at birth in blood cord and at one and three months of life. In preterm infants fed a taurine‐free formula, we found lower plasma taurine levels than in infants of other groups at one and three months of life. In these infants, GBA predominated, with a G/T ratio of 1.1 and 1.4 at one and three months of life, whereas in all other infants TBA predominated with a G/T ratio always

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12568.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

This study was undertaken to characterize the food intake, current feeding situation and nutritional status of children with cerebral palsy and myelomeningocoele. Thirty children with cerebral palsy and 14 with myelomeningocoele were investigated. The children with cerebral palsy were subgrouped into those with diplegia (11 children), dystonia (10 children), hemiplegia (6 children) and ataxia (3 children). Information was obtained from medical records, current dietary recording and clinical and anthropometric examinations. Feeding problems, low energy intake and wasting were frequent among the children with cerebral palsy, particularly those with the dystonic form. Children with myelomeningocoele gave the impression of being overnourished, despite a seemingly relatively low energy intake. It is clear that nutritional and feeding aspects should receive particular attention in the habilitation of children with various disabilities.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12569.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Lilleyman JS and Hann IM.Paediatric Haematology. London: Churchill Livingstone, 1992.

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12570.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12571.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Recent evidence strongly suggests that peroxidative modification of lipids may play a significant role in atherogenesis. In our present research, we investigated if the oxidative stress mediated by oxygen free radicals was a pathophysiologic condition that occurred in the early stages of human development. Thus the aim of this research was to examine lipid peroxidation in human fetal aortas. Human fetal aortas and proximal iliac arteries (n= 8) were obtained from fetuses aged 7 ± 2 months, immediately after autopsy. Lipids from the initial fatty streak lesions (LFS) and the vessels uninvolved (LUV) were extracted by the chloroform/methanol method. Lipid peroxidation levels were measured by two different methods: determination of lipid conjugate dienes (the spectrum trend was recorded from 320 to 200 nm with a spectrophotometer) and malonyldialdehyde (MDA) content (TBA method). We observed that lipid conjugated dienes were present in LFS, but not in LUV, with a characteristic absorption peak at 233 nm. In addition, MDA levels were significantly higher when the LFS = 3.85 ± 0.91 nmol than when the LUV = O.41 ± 0.12 nmol (p<0.001 versus LUV). The presence of lipid peroxidation in our samples could be mediated by free radical production in the first stages of human development. Thus these data suggest that LFS peroxidation mediated by free radicals occurs in the vascular circulation in the early stages of human development. This could influence the progression of vascular damage and atherosclerotic disea

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12572.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

The etiology of retinopathy of prematurity appears to be multifactorial. Introduction of new treatments in neonatal care may add new risk factors. We have analyzed thc relationship between 42 perinatal factors and the development of retinopathy of prematurity in 78 infants with a birth weight<1501 g and/or gestational age<33 weeks. We have also applied a chronological analysis of the maximum and minimum pO2and pCO2values. Retinopathy of prematurity was seen in 37 of 78 infants (47.4%). Nineteen factors were found to be related to the development of retinopathy of prematurity. However, when step‐wise logistic regression analysis was used, only birth weight, number of days of oxygen therapy and use of beta‐blocking agents by the mother before birth were found to be associated with the development of retinopathy or prematurity. The results suggest that medication with beta blockers immediately before birth should be used cautiou

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12573.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

In developing countries,Campylobacter jejunicauses diarrhea and dysentery, especially in children less than one year of age. Breast feeding protects against infectious diarrhea, with milk IgA antibody playing a determining role. Therefore, it has been proposed to increase the protective effect of human milk by vaccinating women of child‐bearing age. To identify antigens which may induce protective breast‐milk IgA, we analyzed 60 strains ofC. jejuniisolated from asymptomatically‐ and symptomati‐cally‐infected breast‐fed children less than 12 months of age. Surface antigens ofc. jejuni, separated by polyacrylamide gel electrophoresis, were probed with breast milk collected concurrently with the fecal sample from whichC. jejuniwas isolated, and specific IgA was developed by immunoblotting. Our results indicate that milk antibodies against three high molecular weight bacterial surface antigens of 95, 110 and 185 kDa are involved in protection of infants infected withC. jejuni (p =0.00964 for one‐tailed Fisher'

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12574.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

In a prospective, population‐based study, 31 patients with pure granulocytopenia lasting longer than six months were followed‐up for up to 7.3 years after diagnosis. Their ages at diagnosis were 0.3–15.5 (median 0.9) years; 17 of the patients were less than 1 year of age. The lowest granulocyte count measured was 0.00–0.60 (median 0.03) × 109/l. During the granulocytopenia, 12 patients suffered from repeated infections but none was life‐threatening. In 21 patients, the granulocyte count normalized spontaneously within 0.5–5.5 (median 1.1) years: the other 10 remain granulocytopenic after follow‐up for 2.5–7.3 (median 3.7) years. We conclude that selective granulocytopcnia, if associated with unimpaired myelopoiesis, is a benign disorder in children and does not. even if prolonged, significantly incrcase thc risk of s

ISSN:0803-5253    

DOI:10.1111/j.1651-2227.1993.tb12575.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY