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| 11. |
Stability study of diltiazem and two of its metabolites using a high performance liquid chromatographic method |
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Biopharmaceutics&Drug Disposition,
Volume 10,
Issue 1,
1989,
Page 107-114
Gilles Caillé,
Louise M. Dub,
Yves Théorèt,
France Varin,
Nicole Mousseau,
Iain J. McGilveray,
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ISSN:0142-2782
DOI:10.1002/bdd.2510100112
出版商:John Wiley&Sons, Ltd.
年代:1989
数据来源: WILEY
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| 12. |
Multiple‐dose pharmacokinetics of the new H1‐receptor antagonist tazifylline in healthy volunteers |
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Biopharmaceutics&Drug Disposition,
Volume 10,
Issue 1,
1989,
Page 115-119
R. Bruno,
I. Jullien,
J. Auger,
A. Iliadis,
R. Dow,
J. McEwen,
J. P. Cano,
H. Pinhas,
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PDF (220KB)
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摘要:
AbstractThe multiple‐dose pharmacokinetics of the new H1‐receptor antagonist, tazifylline, were investigated in healthy volunteers. From single‐dose data, tazifylline appeared to be rapidly absorbed (mediantmaxof 0·6 h) and eliminated (t1/2 □ 1·0±0·2 h). However, plasma levels measured on days 3 and 8 of the multiple‐dose regimen (10 mg b.i.d. for 8 days) indicated moderate accumulation. A two‐compartment model best described multiple‐dose data with a terminal half‐life of 15·6 ± 7·6 h consistent with twice‐dai
ISSN:0142-2782
DOI:10.1002/bdd.2510100113
出版商:John Wiley&Sons, Ltd.
年代:1989
数据来源: WILEY
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| 13. |
Effect of cimetidine on quinidine bioavailability |
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Biopharmaceutics&Drug Disposition,
Volume 10,
Issue 1,
1989,
Page 121-125
Janis J. Mackichan,
Harisios Boudoulas,
Stephen F. Schaal,
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PDF (280KB)
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摘要:
AbstractElevations in quinidine steady‐state serum concentrations have been reported in patients who received cimetidine concurrently.1,2Studies in normal volunteers3,4have shown that areas under the serum concentration‐time curve of orally administered quinidine are higher when quinidine is given during chronic cimetidine therapy as compared to under control conditions. The mechanism for this interaction is generally ascribed to decreased hepatic clearance as a consequence of enzyme inhibition. In this study, we show that cimetidine also decreases the bioavailable fraction of quinid
ISSN:0142-2782
DOI:10.1002/bdd.2510100114
出版商:John Wiley&Sons, Ltd.
年代:1989
数据来源: WILEY
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| 14. |
Masthead |
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Biopharmaceutics&Drug Disposition,
Volume 10,
Issue 1,
1989,
Page -
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PDF (70KB)
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ISSN:0142-2782
DOI:10.1002/bdd.2510100101
出版商:John Wiley&Sons, Ltd.
年代:1989
数据来源: WILEY
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