摘要:

AbstractInteraction between herpesviruses and human immunodeficiency virus (HIV)I is postulated in the progression of HIV disease. In order to evaluate the specific antibody responses directed to Epstein‐Barr virus (EBV) and cytomegalovirus (CMV) and to provide serological evidence suggesting reactivation of these viruses able to accelerate the immunodeficiency, we studied IgA and IgG titres to EBV and CMV in the serum of HIV positive patients in relation to the CD4 cell number.The titres of IgG antibodies to EBV and the prevalence of IgG to CMV were significantly higher i n HIV positive patients compared to control high risk HIV negative subjects. In HIV infected patients, anti‐VCA IgG antibodies increased and anti‐EBNA IgG antibodies decreased progressively in relation t o the decline of D4 cell number whereas anti‐CMV IgG antibodies did not varied significantly at the same time. Anti‐VCA IgA and anti‐EA IgG antibodies were found uncommonly and with low titres. IgA antibodies to EA and CMV were not detected in any patient. The variations in EBV antibody response that we describe in HIV infection were previously reported in other immunodeficiency states and could be distinctive of the

ISSN:0146-6615    

DOI:10.1002/jmv.1890360112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

摘要:

AbstractThe early activation of T‐ and B‐cell responses to cytomegalovirus was studied in immunosuppressed patients. Primary lymphocyte stimulation to cytomegalovirus (CMV) antigen, a measure of T‐helper activity, and anti‐CMV IgG subclass responses were analyzed. Ten patients suffering from primary CMV infection following renal transplantation were studied. Of the ten, nine became positive for CMV induced lymphocyte proliferation 5‐40 weeks after transplantation. Nine showed an almost simultaneous appearance of anti‐CMV IgG1 and three at 3‐32 weeks after transplantation, while one patient synthesized only low levels of anti‐CMV IgG1. The lymphocyte proliferation assays have limited diagnostic value for primary CMV infection in renal transplant patients. The humoral and cellular immune responses seemed to be independen

ISSN:0146-6615    

DOI:10.1002/jmv.1890360113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY

ISSN:0146-6615    

DOI:10.1002/jmv.1890360101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1992

数据来源: WILEY