摘要:

The safety and efficacy of conventional aminoglycoside dosing regimens have been proven in clinical trials. Higher doses at longer intervals may be more effective if they result in higher peak serum levels of the drug, but few trials of “once‐a‐day” dosing have shown improved clinical outcome. The clinical safety of allowing trough serum levels to fall below the minimum inhibitory concentration is not established. Literal “once‐a‐day” dosing will result in drug accumulation and toxicity in patients with reduced renal clearance, and in potential lack of efficacy and the emergence of antibiotic‐resistant organisms in those with increased renal clearance. However, modified “once‐a‐day” dosing, with the interval determined by the individual's renal clearance rate (hence avoiding subtherapeutic trough levels), will avoid these problems.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94111.x

出版商:Wiley    

年代:1996

数据来源: WILEY

摘要:

This article deals with four linked but distinct aspects of care for women with breast cancer, with an emphasis on the pivotal role of the general practitioner:Modern medicine is fast recognising the need for psychosocial support of patients; in fact, for an integrated approach to caring for the whole person at all stages of illness.Oncological treatment of metastatic disease needs to be individualised and based on realistic expectations of outcome balanced against side effects.An open dialogue about the role and appropriateness of so‐called “alternative” or “complementary” therapies is needed.Despite significant improvements in palliative care quality and access in Australia in the last decade, many practitioners still require support and advice in this demanding area of care (particularly about difficult symptom control).

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94112.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94113.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94115.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94118.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94120.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94123.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94125.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94127.x

出版商:Wiley    

年代:1996

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1996.tb94092.x

出版商:Wiley    

年代:1996

数据来源: WILEY