ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120386.x

出版商:Wiley    

年代:1987

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120387.x

出版商:Wiley    

年代:1987

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120388.x

出版商:Wiley    

年代:1987

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120389.x

出版商:Wiley    

年代:1987

数据来源: WILEY

摘要:

A study was carried out in Newcastle to assess responses to influenza vaccines in elderly nursing home patients and in younger adults during 1983 and 1984. The decision to vaccinate the elderly subjects was made by their general practitioners. A concurrent randomized placebo‐controlled trial of the same vaccine was performed in young adult volunteers. Elderly subjects generally possessed higher levels of pre‐existing antibody to the influenzal haemagglutinins that were present in the vaccines than did younger subjects. The highest levels were observed in the 52‐63 years' age group. Younger subjects showed significantly greater responses to vaccines compared with elderly subjects (P<0.05). Peak responses were noted in the 16‐24 years' age group. Of a total of 326 elderly subjects (70% of whom had been vaccinated), six participants, two of whom had been vaccinated, contracted laboratory‐proven influenza during 1983. Only one unvaccinated subject of a total of 365 subjects (50% of whom had been vaccinated) contracted influenza during 1984. In both years illness was produced by strain A/Philippines/2/82.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120390.x

出版商:Wiley    

年代:1987

数据来源: WILEY

摘要:

Prospective daily ratings of premenstrual symptomatology were obtained from 40 women for one full menstrual cycle. Nineteen of these women were complaining of suffering from a premenstrual syndrome. The General Health Questionnaire (GHQ) was administered in the mid‐follicular and late luteal phases of the cycle. Women who were complaining of the premenstrual syndrome showed significant premenstrual increases in premenstrual symptoms, of a magnitude that was significantly greater than those of control subjects. The GHQ scores of the women who were complaining of premenstrual syndrome were significantly higher than those of the control subjects in both the follicular and luteal phases of the cycle. The mean GHQ score of the group with premenstrual syndrome was significantly elevated above the published normal value. Fifty‐six per cent of those who complained of premenstrual syndrome had follicular GHQ scores which were higher than the recommended threshold for clinical psychiatric disturbance. Only 10.5% of the control group were above this threshold. General Health Questionnaire scores were stable across phases of the cycle and were correlated to the severity of symptoms of premenstrual syndrome. Premenstrual Moos Menstrual Distress Questionnaire (MDQ) scores were related strongly to follicular MDQ scores. A high proportion of women who complain of premenstrual syndrome show evidence of a more general psychiatric problem which should be evaluated before therapy.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120391.x

出版商:Wiley    

年代:1987

数据来源: WILEY

摘要:

An enzyme‐linked immunosorbent assay (ELISA) forBordetella Pertussis‐specific immunoglobulin (Ig)A antibody in serum was used to demonstrateB. pertussisinfection. The upper limit of normal for the assay (mean + 3 SD) was established by testing sera that had been collected from a group of healthy blood donors. All 13 patients with clinical whooping cough from whomB. pertussiswas isolated and 25.7% of 218 adults, who were aged 18–81 years, who were referred to a consultant physician for the investigation of a persistent cough, had elevated levels of IgA toB. pertussis. The study confirms theB. pertussisIgA ELISA as a sensitive test for the diagnosis ofB. pertussisinfections and that these infections cause respiratory illness, in particular, persistent cough in adults.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120392.x

出版商:Wiley    

年代:1987

数据来源: WILEY

摘要:

Information on the relative incidence of Crohn's disease and ulcerative colitis was obtained by a prospective investigation at six Melbourne teaching hospitals. One hundred and eleven patients who presented with chronic inflammatory bowel diseases between 1980‐1981 were admitted to the study. Forty (36%) patients were diagnosed as having Crohn's disease and 63 (57%) patients as having ulcerative colitis. The type of chronic inflammatory bowel disease could not be determined in eight (7%) patients. These findings suggest that the relative frequency of Crohn's disease and ulcerative colitis in Melbourne hospitals is within the range that is reported for northern Europe and the United States.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120393.x

出版商:Wiley    

年代:1987

数据来源: WILEY

摘要:

Corticosteroid agents have a major role in the treatment of several renal disorders which have an immune basis. They remain the treatment of choice for minimal‐change glomerulonephritis, inducing remission in over 90% of patients. The role of corticosteroid therapy in patients with membranous glomerulonephritis remains controversial, although an extensive controlled trial indicated benefit from a two‐month course of alternate‐day therapy. Intravenously‐administered methylprednisolone has been shown to benefit rapidly progressive crescentic glomerulonephritis; the benefit is probably comparable to that which is obtained with immunosuppression and plasma exchange. Corticosteroid therapy has improved dramatically the prognosis of glomerulonephritis that is associated with systemic lupus erythematosus and the various forms of vasculitis (excluding Wegener's granulomatosis), although the concomitant use of immunosuppressive therapy in these disorders reduces the required doses of corticosteroid drugs. For the last 20 years prednisolone and azathioprine have been standard therapy to prevent renal allograft rejection. However, corticosteroid agents are used currently in much lower doses or have been replaced by cyclosporin A.

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120394.x

出版商:Wiley    

年代:1987

数据来源: WILEY

ISSN:0025-729X    

DOI:10.5694/j.1326-5377.1987.tb120395.x

出版商:Wiley    

年代:1987

数据来源: WILEY