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Effects of Retinoic Acid on the Development of the Facial Skeleton in Hamsters: Early Changes Involving Cranial Neural Crest Cells |
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Cells Tissues Organs,
Volume 116,
Issue 2,
1983,
Page 180-192
M.J. Wiley,
P. Cauwenbergs,
I.M. Taylor,
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摘要:
Treatment of gravid hamsters with 60 mg/kg of retinoic acid on the 8th day of pregnancy resulted in facial skeletal defects in 100% of the survivors examined by alizarin staining at term. An investigation of the early stages in the development of these malformations indicated that the teratogen induced delayed and disorganized patterns of cranial neural crest cell migration as well as extensive death and damage of crest cells. The results demonstrate that retinoic acid provides a useful tool for studies in the pathogenesis of facial skeletal abnormalities in vivo. Moreover, the extensive defects seen in the teratogen-treated litters at term, together with the results of the microscopical analyses, support the hypothesis that cranial neural crest cells make an important contribution to the development of the mammalian facial skeleton.
ISSN:1422-6405
DOI:10.1159/000145741
出版商:S. Karger AG
年代:1983
数据来源: Karger
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