摘要:

The os penis of male C57BL/Tw mice given 5 daily injections of 100 µg tamoxifen (Tx) starting on the day of birth (day 0) was examined at ages of 5–60 days; the bones of males given Tx injections for 5 days starting at 0–10 days and of those given neonatal injections of 100 µg clomiphene or naf oxidine were examined at 60 days. In the control males given the vehicle alone, the proximal segment of the os penis, composed of a compact cell mass found at day 0, developed at 5 days into the membrane bone with bone marrow and hyaline cartilage; the distal segment, composed of mesenchymatous cells until 10 days, developed at 30 days into fibrocartilage characterized by a distribution of type I collagen. By contrast, in Tx mice, fibrocartilage in the distal segment, and hyaline cartilage characterized by a distribution of type II collagen, and bone marrow in the proximal segment disappeared by 30 days. The maximum area of the proximal and distal segments gradually increased with age in control mice, whereas the proximal segment area remained unchanged in Tx mice. In clomiphene and naf oxidine mice at 60 days the proximal segment was composed of hyaline cartilage; however, the distal segment lacked fibrocartilage. Hyaline cartilage in the proximal segment and fibrocartilage in the distal segment disappeared in all 60-day-old mice given Tx starting within 5 days. Neonatal castration did not suppress the formation of bone marrow and fibrocartilage in the os penis, though the bone size was smaller than in the intact controls. Formation of spines on the glans penis skin was suppressed by Tx given within 5 days. These results suggest that neonatally administered Tx inhibits the postnatal differentiation of the mouse os penis, resulting in aplasia of the distal segment and of bone marrow in the proximal segment and the formation of spines on the glans

ISSN:1422-6405    

DOI:10.1159/000146998

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

This paper studies the central and lateral regions of the growth plate in 15-day-old rats histomorphometrically. We have established two regions within the growth plate. The central region is limited by the secondary ossification center of the epiphysis and the metaphysis, and the lateral region is placed between the perichondral ring and Hert’s marginal germinative zone. This study shows that the lateral region of the growth plate in 15-day-old rats is higher and has more cells than the central region. The proliferative zone in the central region is the lowest part of the two regions. Knowledge of the quantitative differences between growth plate regions aids in the analysis of growth plate histomorphometr

ISSN:1422-6405    

DOI:10.1159/000146999

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The epithelial distribution in the nasal cavity of piglets was studied by serial transverse sections. The epithelial distribution in the nasal cavity of healthy piglets varied according to the age of the animal. The transitional epithelium, which contained goblet cells but no ciliated cells, occupied a smaller proportion of the nasal cavity in the newborn piglets than in the 4-week-old piglets. The ciliated epithelium extended more rostrally in the newborn piglets and covered the non-mineralized rostral portion of the nasal ventral concha. At 28 days of age the rostral cartilaginous concha is overlaid by the transitional epithelium the respiratory epithelium covering the mineralized nasal ventral concha. The variations in the epithelial distribution according to age are discussed with regard to the greater susceptibility of newborn piglets to bacterial infection.

ISSN:1422-6405    

DOI:10.1159/000147000

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The spatial displacement of vertebrae in idiopathic scoliosis is not explicable by forces created by the muscles which act upon the spine only (intrinsic muscles). The trapezius and latissimus muscles are attached to the spinous processes and the upper limb. In keeping with Newton’s third law, these muscles act on the spine as well as upon the upper extremity. The peculiarity of the vertebral anatomy, together with the direction of pull of these muscles, permits an explanation of the biomechanics of the development of ‘idiopathic’ scol

ISSN:1422-6405    

DOI:10.1159/000147001

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

We studied the distribution of intermediate filament proteins during several stages of chick embryo heart development by indirect immunofluorescence and fluorescence-activated cell surface analysis. Vimentin is the predominant intermediate filament during the early stages of cardiac genesis, while desmin appears essentially with maturation. Desmin is the main subunit protein of intermediate filaments in the mature myocyte.

ISSN:1422-6405    

DOI:10.1159/000147002

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The Golgi morphology of the neurons in the human interthalamic adhesion (IA, which is not present in every human brain) is very variable. Four types of Golgi-impregnated neurons were found in the adult human IA: (1) fusiform neurons (most characteristic of the human IA); (2) neurons with an oval perikaryon; (3) triangular neurons (rarely found) and (4) multipolar neurons (polygonal perikaryon and at least 4 primary dendrites). Fusiform neurons as well as triangular and multipolar ones, belong to the isodendritic type, but the neurons with oval perikarya do not.

ISSN:1422-6405    

DOI:10.1159/000147003

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Osteochondrosis is a generalized skeletal disorder that affects the growth cartilage in the growing domestic pig but not in the minipig of wild hog ancestry. In the present study, we compare the ultrastructure of the articular and epiphyseal growth cartilage in the domestic pig with that in the minipig. The domestic pigs had areas of enlarged epiphyseal cartilage with chondronecrosis, which had caused focal impairment of the endochondral ossification, with retention of cartilage in the subchondral bone. Areas of chondronecrosis close to blood vessels were found in the resting zone, with no evidence of thickened cartilage or impaired ossification. The chondronecrosis was surrounded by chondrocytes, organized in small clusters, containing many lipid droplets. The vascular channels adjacent to the chondronecrosis contained degenerated blood vessels. The minipigs showed no areas of enlarged epiphyseal cartilage. A few dead chondrocytes could be seen close to vascular channels which contained morphologically normal blood vessels. We conclude that restricted perivascular chondrolysis may occur in the pig without the presence of vascular degeneration and without progressing to osteochondrosis.

ISSN:1422-6405    

DOI:10.1159/000147004

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The histology of the conchae of the nasal cavity in the guinea pig was investigated by means of conventional light and transmission electron microscopy. The results showed a clear structural difference between the anterior and the posterior portion of the conchae being in the first zone where the vasculature was more numerous. The arterioles and the venules were richly innervated, abounding in cholinergic nerve endings with vesicles of probably peptidergic character. The glands were located in the posterior portion and were constituted by acini, an intercalated and a striated duct. Acini as well as the intercalated duct showed cholinergic nerve endings and vesicles with also a propably peptidergic character. In conclusion the conchae of the nasal cavity of the guinea pig showed marked morphological differences in comparison with those of humans.

ISSN:1422-6405    

DOI:10.1159/000147005

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Swiss, 60-day castrate mice were injected with 0.5, 1.5 or 5.0 mg of testosterone propionate (TP; single dose subcutaneously) 5 days before sacrifice in order to investigate the ability of the submandibular gland (SMG) and other androgen target tissues to recover their normal morphology and function. Some animals were additionally injected intraperitoneally with ZnCl2 (0.14 or 0.28 mg Zn2+/animal per day) during the last 15 days before sacrifice. Only SMG tissue fully recovered by TP treatment. ZnCl2 significantly impaired the dose-dependent recovery of the granular ducts of mouse SMG tissue and that of other organs which display ‘androgenic’ (prostate, epididymis) and ‘anabolic’ responses (bulbocavernosus muscle). Histological examination of testes and epididymides of intact mice injected with ZnCl2 revealed abnormal spermatogenesis with multinucleated cells and acidophilic bodies within the tubular lumen; the circulating levels of testosterone in these animals were low. In vitro, Zn2+ inhibited androgen-binding activity in SMG cytosol, but the binding capacity increased in SMG of zinc-injected animals. It is suggested that zinc, although essential for the androgenic expression, is critical as far as its intracellular concentrations are concerned and that pharmacological doses of Zn2+ determine androgenic suppression by competition at receptor and acceptor

ISSN:1422-6405    

DOI:10.1159/000147006

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Ciliated cysts in the human uterine tube epithelium were investigated with the transmission electron microscope. The cysts were about 3–9 µm in diameter and were provided with many ciliary apparatuses and microvilli. Degenerative changes of these cilia, such as electron-dense round or irregular bodies and amorphous substance, were observed in many cysts, but complete disappearance of ciliary structures was not detected in any ciliated cysts. The ciliated cysts were mostly observed in basal cells and were occasionally found in ciliated cells bordering the tubal lumen. In the basal cells, these cysts distended with the increase in degenerated cilia. Distended ciliated-cyst-containing cells became exposed directly to the tubal lumen. U- or reverse Ω-shaped deep indentations of the apical surface of ciliated cells confirmed the opening of ciliated cysts into the lumen. It was suggested that the ciliated cysts result from the premature differentiation of basal cells or disturbed migration of centrioles in ciliogenic ce

ISSN:1422-6405    

DOI:10.1159/000147007

出版商:S. Karger AG    

年代:1990

数据来源: Karger