摘要:

AbstractA prospective study for histiocytosis X was designed to determine whether “good risk” patients, ie, those without evidence of dysfunction of liver, lung, or hemopoietic system, would respond to single agent therapy; in this case chlorambucil (CMB) used in a dose of 5 mgm/m2/day. If there was no response after an adequate trial period, treatment was initiated with four drugs using a combination of prednisone, vinblastine, cyclophosphamide and methotrexate. There were 26 evaluable patients, 57% of whom were less than two years of age at onset of therapy. There were three complete and four partial responses to CMB for a response rate of 26.9%. Sixteen patients received an adequate trial of four‐drug therapy with three complete and two partial responses for a response rate of 33%. These responses were inferior to those previously reported for either single agents or combined therapy in histiocyto

ISSN:0098-1532    

DOI:10.1002/mpo.2950070302

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA 54‐year‐old woman with epigastric pain had leukocytosis of 73,000/μ1 consisting mainly of atypical lymphoid cells with convoluted and cleaved nuclei resembling Sézary cells; the bone marrow aspirate was nondiagnostic. Skin biopsy was unremarkable. The patient also had hypercalcemia and hemolysis with a positive direct Coombs' test, both of short duration.The arterial oxygen tension was decreased, but there was no demonstrable lung pathology. The patient subsequently developed rapidly enlarging lymphadenopathy. Lymph node biopsy was interpreted as “undifferentiated pleomorphic lymphoma.” Immunologic functional studies revealed that the majority of the peripheral blood atypical lymphoid cells from involved lymph nodes formed rosettes with sheep erythrocytes.The lymphadenopathy regressed transiently after the administration of chemotherapy and the white blood cell count decreased from a maximum of 385,000/μ1 to 3,500/μ1, at which point the arterial oxygen tension returned to normal. The unusual features of this patient are discussed in light of the known characteristics of the various types of T‐cell lymphoproliferat

ISSN:0098-1532    

DOI:10.1002/mpo.2950070303

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

ISSN:0098-1532    

DOI:10.1002/mpo.2950070304

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA case of histiocytosis‐X with multifocal bone involvement and mediastinal soft tissue infiltration leading to superior vena cava obstruction, is presented. The incidence and the causes of superior vena cava syndrome in the pediatric group are discusse

ISSN:0098-1532    

DOI:10.1002/mpo.2950070305

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe courses of 18 children with neurogenic sarcoma (NS) treated at the Children's Hospital of Philadelphia between 1958 and 1979 were reviewed. Their median age was 11 years (range, 0.3–16 years); 12 were female and six male. Eleven children had stigmata of neurofibromatosis (NF). One patient had two separate tumors simultaneously. Nine of the tumors were primary in an extremity; six were intraabdominal, two craniofacial, and two truncal. Eleven of the 18 children had grossly complete surgical removal of the primary tumor, whereas seven had gross residual disease after surgery; none had distant metastases detected at diagnosis. The patients were divided into two groups according to whether treatment was primarily surgical (group A) or multimodal (group B). Treatment for group B patients included surgery, local radiotherapy, and multiple‐agent chemotherapy. Two of 12 patients (17%) treated primarily with surgery are surviving four and 14 years later with no evidence of recurrent disease (NED); both had complete removal of the primary NS. Two additional group A patients relapsed but were retrieved with radiotherapy and multiple‐agent chemotherapy. The other eight patients in group A died of tumor at a median of 14 months from diagnosis. In contrast, five of the six group B patients (83%) treated with adequate multimodal therapy (at least 4,000 rads local radiation plus vincristine, actinomycin D, and cyclophosphamide ± Adriamycin) are relapse‐free and surviving at a median of 27+ months from diagnosis. Nine of the 18 patients are free of disease, four with and five without NF. The results suggest that multimodal therapy similar to that for rhabdomyosarcoma should be used for children with neurogenic

ISSN:0098-1532    

DOI:10.1002/mpo.2950070306

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractWe have observed two cases of staphylococcal myositis in patients with acute lymphocytic leukemia which are distinguished from previously reported cases by a history of cutaneous vasculitis overlying the area of subsequent infection.

ISSN:0098-1532    

DOI:10.1002/mpo.2950070307

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractTwenty previously untreated patients with small cell carcinoma of the lung were treated with cyclophosphamide, 400 mg/m2, and Adriamycin, 40 mg/m2IV on day 1, followed by cytosine arabinoside, 20 mg/m2, every 12 hours subcutaneously on days 5–9; this regimen was repeated every 28 days. On days 14–28 of the first cycle, each patient received 3,000 rads to the primary tumor and whole brain. Following eleven courses, Adriamycin was discontinued and patients received cyclophosphamide, 800 mg/m2IV on day 1 and methotrexate, 15 mg/m2IV on days 5–7. This regimen was repeated every 28 days. Toxicity included nausea, vomiting, alopecia, leukopenia, thrombocytopenia, and esophagitis. Overall response rate was 65%. Median survival in limited disease was 14.5 months, and in extended disease it was 4.5 months. This combination is active in localized small cell carcinoma but provides no superiority over other reg

ISSN:0098-1532    

DOI:10.1002/mpo.2950070308

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA pilot study suggesting the usefulness of intravenous diazepam as an antiemetic for adult patients receiving cis‐diamminedichloroplatinum is presented. Observations included 24 patients and 34 courses of therapy. Patients received diazepam and prochlorperazine, and the incidence of vomiting and subjective evaluation of nausea were compared to previous courses of therapy with prochlorperazine alone. A positive response was observed in 87% of the patients. Use of other antiemetics is briefly reviewe

ISSN:0098-1532    

DOI:10.1002/mpo.2950070309

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe combination of 5‐fluorouracil (5‐FU), methyl‐1,3‐cis(2‐chlorethyl)‐1‐nitrosourea (methylCCNU), and vincristine (VCR) has been reported to produce a 43.5% response rate in metastatic colorectal cancer, although subsequent studies did not produce such good response rates. The clinical trial reported here was undertaken to assess the reported results. In 52 evaluable patients the overall response rate was 11%. No complete remissions were observed. Six patients with colon carcinoma had a partial remission lasting for a median of ten months, with a median survival of 15 months. No responses were observed in rectosigmoid cancer. The median survival for nonresponders was 7.5 months. Thirty‐three percent of the patients had significant hematological toxicity (white count ≤ 1,000/mm3, platelets ≤ 50,000/mm3); 58% of the patients experienced nausea and vomiting; and 32% experienced some degree of neurotoxicity. In our hands the combination of 5‐FU, methylCCNU, and VCR produced a response rate of 11% in metastatic colorectal cancer with a considerab

ISSN:0098-1532    

DOI:10.1002/mpo.2950070310

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe cytogenetics in the study of a patient with acute lymphoblastic leukemia are presented. Initially, a large proportion of both unstimulated and phytohemagglutinin (PHA)‐stimulated blood mitoses showed an abnormal karyo‐type with a 7;12 translocation and a trisomy 19. At the time of relapse, a PHA‐stimulated culture showed the clonal abnormality as well as dicentric chromosomes in normal cells, the latter possibly resulting from trea

ISSN:0098-1532    

DOI:10.1002/mpo.2950070311

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY