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1. |
Cytogenetic study of 130 childhood acute nonlymphocytic leukemias |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 227-232
Guy Leverger,
Alain Bernheim,
Marie‐Thérèse Daniel,
Georges Flandrin,
Gérard Schaison,
Roland Berger,
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摘要:
AbstractCytogenetic studies performed on 130 consecutive childhood acute nonlymphocytic leukemias (ANLL) investigated in the same center between 1977 and 1986 are reported. The incidence of clonal chromosomal abnormalities was 68.5% with uneven distribution among the groups of the FAB nomenclature. The high incidence of t(8;21) translocation cases which was 58.6% of M2 ANLL cases was remarkable. Complete remission rate was lower (P<0.05) in ANLL with all karyotypically abnormal metaphases (AA) than in the other ANLL (NN with only normal metaphases and AN with a mixture of normal and abnormal metaphases). Median survival was also shorter in AA ANLL than in AN and NN cases (P<0.01). Median survival was different according to karyotype abnormalities: 11q anomalies and t(15;17) were not associated with a good prognosis and the t(8;21) is not associated with a particularly long median survival (16 months) when compared with other ANLL as opposed to the results of others. The longest survival (26 months) was observed in patients with acute myelomonocytic leukemia with bone marrow eosinophilia. It may be concluded that chromosome studies have a prognostic value in childhood ANLL.
ISSN:0098-1532
DOI:10.1002/mpo.2950160402
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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2. |
Reproductive problems and birth defects in survivors of Wilms' tumor and their relatives |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 233-240
Julianne Byrne,
John J. Mulvihill,
Roger R. Connelly,
Donald A. Austin,
Grace E. Holmes,
Frederick F. Holmes,
Howard B. Latourette,
J. Wister Meigs,
Louise C. Strong,
Max H. Myers,
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摘要:
AbstractIn a retrospective cohort study of 47 Wilms' tumor survivors and their 77 sibling controls, female survivors had a fourfold excess risk (risk ratio, 4.1; 95% confidence interval, 1.7‐10.1) for any adverse livebirth outcome, including birth defects, compared with their sibling controls. Wives of male survivors had no apparent excess risk for problem pregnancies. The families had a number of severe reproductive problems and major birth defects, such as primary amenorrhea in two survivors, bicornuate uterus in two survivors and one control, and mental retardation in one male survivor and a male control. The son of a female survivor died after bilateral Wilms' tumors. Birth defects in the offspring of female survivors are compatible either with intrauterine constraint, possibly due to radiation‐induced fibrosis or with the complex of malformations associated with Wilms' tumor. Female survivors of Wilms' tumor appear to be at increased risk for a variety of reproductive problems, from sterility to fetal loss, early delivery, and birth defects in offspring. Furthermore, relatives of survivors of Wilms' tumor may be at risk of having associated birth defects, with clinically significant consequen
ISSN:0098-1532
DOI:10.1002/mpo.2950160403
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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3. |
Male reproductive function in long‐term survivors of childhood cancer |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 241-247
Norman Jaffe,
Margaret P. Sullivan,
Hubert Ried,
Hallie Boren,
Robert Marshall,
Marvin Meistrich,
Moshe Maor,
Miguel Da Cunha,
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摘要:
AbstractWe evaluated reproductive function in 27 male long‐term survivors of childhood cancer treated during the prepubertal and pubertal period. Sperm samples were obtained from 23 patients; four who refused to provide specimens indicated that they had fathered normal healthy children. Thirteen patients were 12 years old or younger at the time of diagnosis and initiation of therapy. Chemotherapy was calculated according to the cumulative amount of drug administered and correlated with the surface area. Sterility was associated with large doses of single alkylating agents or reduced doses administered with other agents in combination regimens. It was noted in boys treated in both the prepubertal and pubertal period. Sterility was also observed in patients who received testicular radiation alone or in combination with chemotherapy. However, it was not an inevitable consequence in all patients, despite treatment with similar or identical regimens. Fertility potential could not be predicted by clinical examination (testicular size) or gonadotrophin and testosterone values. The results were compared to published reports of treatmentinduced sterility in adult males. Additional investigations are required to establish more accurate correlations of dosage with reproductive potentia
ISSN:0098-1532
DOI:10.1002/mpo.2950160404
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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4. |
Long‐term survival of children with acute non‐lymphoblastic leukemia |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 248-254
Lorrie F. Odom,
Helvise Morse,
David G. Tubergen,
Marilyn Blake,
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摘要:
AbstractResults of a pilot protocol employing chemoimmunotherapy for treatment of 23 children with acute non‐lymphoblastic leukemia consecutively diagnosed between 1975 and 1979 are reported. Twenty‐two children achieved remission, ten of whom are surviving 6.5–9.5 years after completion of primary systemic therapy (median 7.8 years). Treatment consisted of intermittent courses of Daunomycin, Cytosine Arabinoside, 6‐Thioguanine, VP‐16, with or without Decadron.Connaught BCC applied between courses of chemotherapy for the first 8 months of treatment, and cranial irradiation/intrathecal Cytosine Arabinoside in early first remission. Five patients with leukemic cells in spinal fluid at diagnosis had myelomonoblastic or monoblastic subtypes and a median diagnostic white blood cell count (WBC) of 149,000/mm3compared with a median WBC of 12,000/mm3for the other 18 patients
ISSN:0098-1532
DOI:10.1002/mpo.2950160405
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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5. |
Prepubertal endocrine follow‐up in subjects with Wilms' tumor |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 255-258
Laura Perrone,
Antonio A. Sinisi,
Romolo Sicuranza,
Maria T. Di Tullio,
Paolo Indolfi,
Maria G. Giuliano,
Antonio Bellastella,
Michelangelo Faggiano,
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摘要:
AbstractTwenty‐three prepubertal subjects treated for Wilms' tumor (10 males and 13 females) were endocrinologically evaluated off therapy from 0.5 to 4.08 years. They were divided into two groups: 11 subjects (6M, 5F) who had received chemotherapy only (group 1) and 12 (4M, 8F) who had in addition received abdominal radiation (1,500–3,000 rads) (group 2). Follicle‐stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyroid‐stimulating hormone (TSH), free thyroxine (FT4), free tri‐iodo thyronine (FT3), testosterone (T), estradiol‐17β (E2), and cortisol (F) were measured by radioimmunoassay (RIA). Plasma levels of TSH, PRL, FT4, FT3, and F were normal in both groups, as were FSH, LH, T, and E2 in group 1. In group 2, female subjects showed FSH levels significantly higher than controls, while LH and E2 were normal; male subjects showed significantly higher LH levels, while FSH and T levels were normal. These results indicate that in the treatment protocol used by us for Wilms' tumor (WT), chemotherapy does not affect endocrine function, whereas abdominal radiation seems to damage gonadal function directly. The present findings indicate that gonadal damage may be revealed in WT before puberty not only in females, as has been previously reported, but also in m
ISSN:0098-1532
DOI:10.1002/mpo.2950160406
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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6. |
Radiation therapy in soft‐tissue lesions in histiocytosis X (Langerhans' cell histiocytosis) |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 259-262
Razvan Gramatovici,
Giulio J. D'Angio,
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摘要:
AbstractLangerhans' cell histiocytosis (LCH) (previously histiocytosis X) is an infrequent disease with protean clinical manifestations and an unpredictable course.The role of radiotherapy in the soft tissue complications of LCH was evaluated in this retrospective study of 40 patients seen in two major Philadelphia institutions between 1970 and 1984. The patients were divided into two groups according to the extent of disease: unifocal versus multifocal. There was a higher rate of complete response in the unifocal form (4 of 12 patients), but this was associated with a high rate of spontaneous remissìons (6 out of 12 patients). Multifocal LCH has a more aggressive course, and the major organs involved (lung, liver, and spleen) did not respond to radiotherapy. Eight patients had diabetes insipidus, and none of them responded to radiotherapy or chemotherapy. Autopsies were performed in two patients with diabetes insipidus who died of disease. There were no pathologic changes in the pituitary gland or stalk, hypothalamus, or supraoptic nuclei
ISSN:0098-1532
DOI:10.1002/mpo.2950160407
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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7. |
Chemotherapy side effects in pediatric oncology patients: Drugs, age, and sex as risk factors |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 263-268
Samuel Lebaron,
Lonnie K. Zeltzer,
Christine Lebaron,
Shannon E. Scott,
Paul M. Zeltzer,
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摘要:
AbstractNausea, vomiting, and the extent to which chemotherapy‐bothered children were assessed by patient and parent ratings for 31 children (65 courses) receiving combination chemotherapy with either highdose cyclophosphamide or doxorubicin /daunorubicin. Patients and parents both reported more severe vomiting with cyclophosphamide than with the anthracyclines. The use of antiemetics did not affect emesis for the former drug; for the anthracyclines, there was more severe emesis for courses with antiemetics than for those with none. Adolescents reported more severe nausea than children, and females reported both more nausea and bother than males. There were no significant age or sex findings for parent reports. The findings suggest that chemotherapy‐related nausea and vomiting in children is a complex phenomenon not accounted for by drugs al
ISSN:0098-1532
DOI:10.1002/mpo.2950160408
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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8. |
Phase II study of bisantrene administered by continuous 72‐hour infusion for advanced pancreatic adenocarcinoma |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 269-270
Robert F. Marschke,
Larry K. Kvols,
Stephen A. Cullinan,
John A. Laurie,
James A. Mailliard,
Loren K. Tschetter,
Michael J. O'Connell,
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摘要:
AbstractEighteen ambulatory patients who had proven metastatic adenocarcinoma of the pancreas and measurable disease but no previous chemotherapy were treated with bisantrene given by constant central intravenous infusion over72 hours at a total dose of 300 mg/m2repeated every 3 to 4 weeks. No objective regression was seen. The median interval to progression was 6 weeks; the median survival was 14 weeks. Primary toxic reactions were nausea, vomiting, and leukopenia. In no instance were these life‐threatening. When administered by the method we used, bisantrene cannot be recommended for treatment of advanced pancreatic adenocarcinom
ISSN:0098-1532
DOI:10.1002/mpo.2950160409
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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9. |
The relevance of the statement “complete response” in childhood rhabdomyosarcoma |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 271-272
Modesto Carli,
Giorgio Perilongo,
Paolo Grotto,
Guido Pastore,
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ISSN:0098-1532
DOI:10.1002/mpo.2950160410
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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10. |
Isosexual precocious puberty associated with an ovarian mass |
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Medical and Pediatric Oncology,
Volume 16,
Issue 4,
1988,
Page 273-279
Giulio J. D'Angio,
Audrey E. Evans,
Giorgio Perilongo,
Arthur Ross,
Daniel Hale,
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ISSN:0098-1532
DOI:10.1002/mpo.2950160411
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1988
数据来源: WILEY
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