摘要:

AbstractThe aim of this study was to seek a better treatment for patients with inoperable or recurrent stomach cancer. Seventy patients were randomly allocated to receive courses of treatment with either A (5‐Fluorouracil plus radiotherapy) or B (5‐Fluorouracil plus Imidazole Carboxamide Dimethyl Triazeno plus Vincristine plus Bis‐Chloroethyl Nitrosourea plus radiotherapy). Only 59 of these patients were evaluable. The median survival time of patients allocated to Group A was 220 days and Group B was 199 days. Seventeen of 31 patients in Group A and 10 of 28 patients in Group B had objectively documented remission. The median survival time of responders was 222 days for Group A and 410 for Group B. While it would appear that those patients who respond to the more intensive treatment do better, a larger percentage of patients responded to the simpler treatment regimen of 5‐Fluorouracil plus radio

ISSN:0098-1532    

DOI:10.1002/mpo.2950020202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compared to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.

ISSN:0098-1532    

DOI:10.1002/mpo.2950020203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractTwo cell‐surface markers, rosette formation with sheep erythrocytes (E‐rosette) as a T‐cell marker and rosette formation with bovine erythrocyte‐antibody‐complement complex (EAC‐rosette) as a B‐cell marker were determined on peripheral blood lymphocytes and lymphoblasts from normal and 89 children with acute lymphoblastic leukemia (ALL).In the majority of the patients (12/15 untreated patients and 6/11 patients in relapse), lymphoblasts exhibited neither E‐ nor EAC‐rosette formation. Lymphoblasts from one untreated patient with mediastinal mass displayed E‐(50%) and EAC‐rosette formation (15%). In 3 of 11 patients in relapse, lymphoblasts displayed an increase in EAC‐rosette formation with progressive disease. In the remaining patients with active disease, a small and variable proportion of lymphoblasts expressed E and/or EAC‐rosette formation. In 63 patients in remission, percentages of E‐ and/or EAC‐rosette were similar (p>0.05) to those of control.The results indicate a wide heterogeneity with respect to expression of lymphocyte membrane markers in lymphoblasts and in normal lymphocyte

ISSN:0098-1532    

DOI:10.1002/mpo.2950020204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe development of an effective therapeutic regimen for acute lymphocytic leukemia (ALL) of childhood is described. By careful surveillance of toxicity and efficacy, positive modifications of treatment strategy were achieved without resorting to classically randomized trials. The resultant protocol utilizes vincristine‐prednisone induction followed by asparaginase consolidation, intensive intermittent combination maintenance chemotherapy with adriamycin as a major component, and cranial radiotherapy plus intrathecal methotrexate for central nervous system prophylaxis. Preliminary analysis suggests that this regimen may result in prolonged continuous complete remission in at least 80% of children with AL

ISSN:0098-1532    

DOI:10.1002/mpo.2950020205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe marginal neutrophil leukocyte pool and the bone marrow neutrophil reserves were assessed in 43 patients with lymphoreticular malignancies, using epinephrine and steroid stimulation. Thirty‐three patients were studied before staging, following splenectomy, before and after nodal irradiation and during remission induction chemotherapy. Ten patients in partial remission were studied after 12 months or more of chemotherapy. A neutrophil count of 1,500–2,500 cells/mm3is not a sufficient guide for modifying the chemotherapy. The response to steroid stimulation may be a more dependable guide to evaluate the patient's potential risk for infect

ISSN:0098-1532    

DOI:10.1002/mpo.2950020206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThis study assesses the effects of oral BCG, as a single agent, on tumor progression and on cell‐mediated immune function in patients with metastatic malignant melanoma. Thirty patients were studied including 22 with measurable metastatic lesions and 8 with no detectable disease, following treatment of metastases by surgery, radiotherapy, or 5‐(3, 3‐dimethyl‐1‐triazeno)‐imidazole‐4‐carboxamide (DTIC DIC). Oral BCG was given in doses of 120–240 mg, 1–3 times per week for periods ranging from 9 to 80 weeks and to total doses of from 1.2 to 20.1 gm. Patients were assessed by direct measurements of tumor mass, PPD skin tests, and in vitro blastogenic responses to PPD and PHA. Of the 22 patients with measureable disease, 19 showed tumor progression and none showed regression of any lesion. Of the 8 without apparent disease, 5 remained stable and 3 had tumor recurrence. Of the total group of 30 patients, 8 showed some increased sensitivity to skin testing with PPD. Of 19 tested, 3 showed an increased PPD response in vitro, while 3 showed a decreased response. Six of 20 tested showed an increased PHA response in vitro. Oral BCG alone was not effective as an antitumor agent in patients with metastatic

ISSN:0098-1532    

DOI:10.1002/mpo.2950020207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractCombination chemotherapy with adriamycin and DTIC was used in 102 evaluable patients under 15 years of age who had previously treated metastatic solid tumors. Responses, defined as 50% or more reduction in all tumor masses, occurred in 10 out of 27 patients with neuroblastoma, 3 out of 8 patients with Wilms tumor, 7 out of 15 patients with Ewing sarcoma, 2 out of 6 patients with osteosarcoma, 5 out of 13 patients with rhabdomyosarcoma, and 15 out of 33 patients with miscellaneous tumors which included a patient who had a complete regression of an extensive juvenile angiofibroma. Response rate to combination chemotherapy with adriamycin and DTIC in patients with Ewing sarcoma was significantly superior to the response rate obtained with adriamycin alone in another Southwest Oncology Group Study. Major toxicity included nausea, vomiting, myelosuppression, high incidence of pneumocystis carinii pneumonia (5 patients) and congestive heart failure (4 patients). There were 7 drug‐associated deaths due to sepsis (1), pneumocystis carinii pneumonia (4), and congestive heart failure (2

ISSN:0098-1532    

DOI:10.1002/mpo.2950020208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractForty‐five children with acute nonlymphoblastic leukemia in relapse received a total of 56 courses of L‐asparaginase combined with vincristine and prednisone. The complete remission rate of 40% (12 of 30 trials) in patients resistant to vincristine and prednisone was almost identical to that in children still sensitive to vincristine and prednisone (42%, 11 of 26 trials). The complete remission rate of 38% (14 of 37 exposures) in those children who had not received L‐asparaginase previously compared favorably with the complete remission rate in those children who had received prior L‐asparaginase (47%, 9 of 19 exposures). Forty‐seven of the 56 induction trials were in children with 1 or more remissions and 14 of these were in children with 3 or more prior remissions. Toxicity wa

ISSN:0098-1532    

DOI:10.1002/mpo.2950020209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

Abstractβ‐thioguanine deoxyriboside (βTGdR) is a purine nucleoside derivative which was studied alone or in combination with arabinosyl cytosine (Ara‐C) in patients with solid tumors and acute leukemia. No significant responses were observed in 22 patients with solid tumors. The response rate with βTGdR alone in acute leukemia was 26% and in combination with Ara‐C was 24%. Responses were generally of short duration. Toxicity included myelosuppression, nausea, stomatitis, hyperpigmentation, photosensitivity, and liver function abnor

ISSN:0098-1532    

DOI:10.1002/mpo.2950020210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractA randomized prospective study of Mitomycin‐C and its N‐methyl derivative, Porfiromycin, was conducted. Thirty‐two patients with disseminated gastrointestinal cancer or other disseminated abdominal adenocarcinoma were treated with Mitomycin‐C 31 patients received Porfiromycin. Both drugs were given by acute intermittent bolus schedule (Mitomycin‐C, 22.5 mg/M2or Porfiromycin, 75 mg/M2every 6–8 weeks as a single bolus i.v. injection). Eleven patients (34%) who received Mitomycin‐C entered into partial remission. In 10 of the 31 patients (32%) receiving Porfiromycin, partial remission occurred. Analysis by tumor type demonstrated that in the Mitomycin‐C‐treated group responses occurred in 4 of 12 patients with colorectal carcinoma, in 4 of 9 with upper GI cancers, and in 3 of 11 with ovarian cancer. Correspondingly in the Porfiromycin group responses occurred in 2 of 12 colorectal carcinoma patients, in 3 of 7 upper GI cancer patients, and in 5 of 12 ovarian cancer patients. Both drugs produced significant myelosuppression; however, Porfiromycin toxicity appeared more cumulative. Further clinical trial of Mitomycin in an acute intermittent bolus schedule

ISSN:0098-1532    

DOI:10.1002/mpo.2950020211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY