摘要:

AbstractThirty‐two evaluable good risk patients with multiple myeloma received a 70‐day tapering course of prednisone beginning at a dose of 1.2 mg/kg/day. Forty‐four percent of the patients demonstrated objective evidence of response to this treatment. Although the median time to disease progression for the prednisone‐treated group was shorter than for patients randomized to receive prednisone with alkylating agents or who were treated with alkylating agent alone, the results from this trial indicate that prednisone, by itself, may produce objective responses. Caution must be used interpreting trials of new agents in myeloma when such treatments are combined with corticosteroid adminis

ISSN:0098-1532    

DOI:10.1002/mpo.2950130502

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe emergence of revised definitions for the high‐risk patient with cutaneous malignant melanoma prompts us to re‐examine the current status of adjuvant therapy in this disease. We wish to address the question, “once a cutaneous melanoma is surgically removed and the patient is currently free of disease but at high risk for metastases, what can be done to prevent recurr

ISSN:0098-1532    

DOI:10.1002/mpo.2950130503

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractClinical staging and factors related to survival were evaluated in 44 stage IV‐S and 44 stage IV patients with neuroblastoma, ages 0 to 12 months, seen at Childrens Cancer Study Group (CCSG) institutions from 1972 to 1979. In 73 patients with complete surgical staging, the life‐table projected survival at 3 years was 91% for stage IV‐S and 44% for stage IV. The only deaths in stage IV‐S disease occurred in three patients less than 2 months old at diagnosis. In stage IV‐S, 3 to 12 months old at diagnosis, the disease‐free survival was 97%. Chemotherapy or radiation therapy did not appear to improve the survival rate in stage IV‐S.These studies further document a significant clinical and biologic difference between patients with stage IV and stage IV‐S neuroblastoma and suggest that they require different therape

ISSN:0098-1532    

DOI:10.1002/mpo.2950130504

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractAvascular necrosis of bone (AVNB) is a known complication of systemic adrenocorti‐costeroid therapy, and one which is thought to be dose‐related. However, despite the large amounts of prednisone which have been used in the standard treatment of acute lymphocytic leukemia (ALL), AVNB rarely has been reported in children with that disease. We described our experience with one adolescent with ALL who developed multifocal AVNB presenting as bone pain after aggressive chemotherapy that included a high cumulative dose of corticosteroids as well as other antitumor agents, some of which also have been associated with AVNB. Four similar cases from the literature are reviewed. Because the bone pain of AVNB can mimic that of leukemic relapse, this is an important entity to be aware of, and one which may become more common with increasingly aggressive combination chemother

ISSN:0098-1532    

DOI:10.1002/mpo.2950130505

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractMulticentric reticulohistiocytosis (MR) is a syndrome characterized by papulonodular skin lesions, a debilitating polyarthritis, and characteristic histologic findings. It is a rare disorder with only 82 cases reported. Twenty‐eight percent had an associated neoplasm. Hematologic malignancies (four) and neoplasms arising from the breast (four), cervix (three), stomach (three), ovary (two), colon (two), lung (one), pleura (one), and from an unknown source (two) were all seen associated with MR. Eleven cases (including our own) were available for review. The papulonodular skin involvement was the initial manifestation (alone or concurrent with the polyarthritis) in 90% of our cases. The diagnosis of MR preceded that of the associated neoplasm in 73% of the cases. A case report is presented illustrating the relapse of MR before the clinical relapse of the associated tumor, and the response of both the tumor and MR to combination chemotherapy with cyclophosphamide, methotrexate, 5‐fluorouracil, and prednisone when prednisone and aspirin alone failed to relieve the symptoms of MR. Steroids were not beneficial in the patients reviewed. The best management of MR associated with a neoplasm is the best management of the primary neoplasm. Cytotoxic chemotherapy including cyclophosphamide should be considered if there is progression of the MR in order to control the symptoms of MR and prevent a progressive debilitating arthri

ISSN:0098-1532    

DOI:10.1002/mpo.2950130506

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSarcoma metastatic to cerebral parenchyma, although rare, occurs more frequently than generally recognized. With increased duration of survival due to multi‐modal therapy, more CNS metastases are being found. A literature search occasioned by a patient with metastatic sarcoma has produced some interesting result

ISSN:0098-1532    

DOI:10.1002/mpo.2950130507

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractOncologists' attitudes toward therapy for his or her own hypothetical cancer have not been studied, and they may influence therapeutic decisions for patients. This study compared attitudes of oncologists at different levels of training toward therapy for their own hypothetical cancer. Those with limited oncology experience had high expectations for treatment, as expressed in their acceptance of all therapeutic modalities for their own disease. Early intensive inpatient oncology experience (first year of training) led to disenchantment, and rejection of various therapies. Further outpatient experience led to an increased acceptance of therapy again, and those finishing second and third year of oncology training, and senior medical staff in oncology, had high expectations for treatment. These results suggest an evolution of attitudes toward therapy with training and experience.

ISSN:0098-1532    

DOI:10.1002/mpo.2950130508

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0098-1532    

DOI:10.1002/mpo.2950130509

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractTumors of unknown origin (TUOs) account for 3% of cancers and represent the eighth‐most common cancer diagnosis. Although TUOs are commonly classified by their histological presentation, examination of the location of the metastases is equally important. When the histological type and location of metastases are both known, a finite number of common clinical syndromes emerge and one can predict the most common occult primarie

ISSN:0098-1532    

DOI:10.1002/mpo.2950130510

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0098-1532    

DOI:10.1002/mpo.2950130511

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY