ISSN:0098-1532    

DOI:10.1002/mpo.2950130202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSince passage of the National Cancer Act in 1971, the NCI Centers Program has promoted the establishment and the development of cancer centers of many types throughout the nation. These now include 20 comprehensive cancer centers, as well as a number of clinical and basic science centers that are supported through NCI core grants. Scientific productivity at NCI‐supported centers has been high. While cancer center core grants usually represent only a small proportion of the total extramural research support for a given institution, they are essential in providing shared resources and in pulling together the various component research programs of a center into a unified program. The future directions of the NCI centers program as a whole, as well as the role of cancer research centers within their communities and regions, are discusse

ISSN:0098-1532    

DOI:10.1002/mpo.2950130203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe effect of testicular irradiation on Leydig cell function has been studied in a group of boys irradiated between 1 and 5 years earlier for a testicular relapse of acute lymphoblastic leukaemia. Six of the seven boys irradiated during prepubertal life had an absent testosterone response to HCG stimulation. Two of the four boys irradiated during puberty had an appropriate basal testosterone level, but the testosterone response to HCG stimulation was subnormal in three of the four. Abnormalities in gonadotrophin secretion consistent with testicular damage were noted in nine of the 11 boys. Evidence of severe Leydig cell damage was present irrespective of whether the boys were studied within 1 year or between 3 and 5 years after irradiation, suggesting that recovery is unlikely. Androgen replacement therapy has been started in four boys and will be required by the majority of the remainder to undergo normal pubertal development.

ISSN:0098-1532    

DOI:10.1002/mpo.2950130204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSixty‐three children with ALL in CCR and treated according to a standard therapy protocol were immunized with the 14‐valent pneumococcal vaccine. Forty‐six children were vaccinated 1, 3, or 6 months following initial induction remission; 15 were vaccinated 4–6 weeks following successful completion of 30 months of antileukemia therapy; and two were vaccinated at the time of diagnosis. Response to the vaccine was suboptimal and by the 6‐month follow‐up there were only two serotypes for which more than half the patients tested had>300 ng anti

ISSN:0098-1532    

DOI:10.1002/mpo.2950130205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSeventeen patients with advanced non‐small‐cell lung cancer (NSCLC) were entered on a combination chemotherapy protocol including vindesine and high‐dose cisplatin. All patients had measurable disease and had not previously received chemotherapy. All patients entered were evaluable for toxicity and response. Tumor regression was limited to one complete and one partial response (response rate, 11.7%; 95% confidence limits, 0 to 27%). The complete and partial response lasted 260 + and 82 days, respectively. For the 15 nonresponding patients, the median time to disease progression was 76 days. Median survival was 141 days for the whole group. Significant toxic effects were vindesine‐related peripheral neuropathy and cisplatin‐in‐duced emesis. Myelosuppression was mild and manageable. The response for the vindesine‐cisplatin combination observed in our study is inferior to that seen in a previous vindesine‐cisplatin trial reported by others. Thus, the true value of this two‐drug regimen in the treatment of NSCLC remains

ISSN:0098-1532    

DOI:10.1002/mpo.2950130206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractMedical students' attitudes toward cancer and patients with cancer were studied prior to and following a required pediatric clerkship which included contact with children on an oncology service. Emphasis in the study was placed on the students' reactions to the child with cancer, and these were compared with the same students' attitudes in the context of the adult with cancer or general oncology.Early diagnosis is regarded as of more significance, and an aggressive therapeutic response following diagnosis of more urgency when the patient is a child. These attitudes, recognizing the importance of early diagnosis and expressing strong approval of aggressive therapy for the pediatric patient, increased during the clerkship. The students strongly supported a program aimed at return of the child to his normal activities with the least delay; recognized the special significance of long‐range surveillance for secondary effects in the pediatric patient; and recommended the “center” as opposed to the community hospital as the site for care of the child with cancer. In other areas of cancer management, including (a) the importance of psychosocial support, (b) the problems of emotional involvement of the physician with the patient, and (c) care of the dying patient, attitudes toward patients in the two age groups was not significantly diff

ISSN:0098-1532    

DOI:10.1002/mpo.2950130207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

ISSN:0098-1532    

DOI:10.1002/mpo.2950130208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSterile hemorrhagic cystitis following cyclophosphamide (Cph) therapy is a relatively frequent and well‐documented phenomenon. On the other hand, cancer of the urinary bladder associated with Cph therapy is rarely observed. We present two cases and summarize 32 patients reported in the literature.Thirty patients had malignant disease elsewhere, 27 of them nonsolid tumors. The other four patients received treatment with Cph for nonmalignant disease (systemic lupus erythematosus—3; rheumatoid arthritis—1). The bladder tumor developed several months to years after treatment. In 20 patients hemorrhagic cystitis antedated the tumors.We conclude that hemorrhagic cystitis in patients on Cph therapy should indicate at least temporary withdrawal of the drug. The decision to resume treatment should be taken with extreme caution considering the risk of the development of bladder c

ISSN:0098-1532    

DOI:10.1002/mpo.2950130209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA patient with carcinoma of the breast, who developed a clinical syndrome resembling agnogenic myeloid metaplasia, is described. She was found to have secondary myelofibrosis with metastatic carcinoma of the marrow, extensive extramedullary hematopoiesis resulting in massive splenomegaly, and leukoerythroblastosis. These findings are rare and myeloid metaplasia with striking extramedullary hematopoiesis causing massive splenomegaly and mimicking agnogenic myeloid metaplasia is seldom seen in patients with metastatic carcinoma. Previous case reports of secondary extramedullary hematopoiesis simulating agnogenic myeloid metaplasia (AMM) in patients with solid tumors are also reviewed.

ISSN:0098-1532    

DOI:10.1002/mpo.2950130210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA nine‐year‐old girl was fortuitously found to have a symptomless metastatic islet cell tumour (apudoma) of the head of the pancreas, the first to be described in a child. The tumour has not changed in size over 3 years and the patient has shown normal growth and development. Initial chemotherapy had no eff

ISSN:0098-1532    

DOI:10.1002/mpo.2950130211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY