摘要:

AbstractRecent reports have suggested that elevations of serum dopamine‐B‐hydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the disease course of five patients with neuroblastoma. DBH activities did not indicate clinical course, therapies, or prognosis. Dilution studies revealed an age‐related alteration in DBH effectors and they suggest that these may be different in neurobla

ISSN:0098-1532    

DOI:10.1002/mpo.2950060202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe biologic impact and clinical toxicity of Corynebacterium parvum administered at a dose of 5 mg/M2by intravenous or subcutaneous routes were evaluated in 18 children receiving combination chemotherapy for maintenance of acute lymphoblastic leukemia (ALL) in remission. Several nonspecific immunologic and hematologic parameters were evaluated. Patients were also monitored for changes in cutaneous sensitivity to histamine. No changes in any parameter were observed in patients after only one course of C parvum injection. However, after 6‐10 courses, glass‐adherent peripheral blood leukocytes of C parvum‐treated patients augmented the response of PHA‐stimulated autologous lymphocytes. In all nine patients studied who received C parvum injection subcutaneously for at least six months, there were significant increases in the mean bone marrow myelocyte‐erythrocyte (ME) volumes compared to pretreatment values. These results suggest that periodic evaluations are desirable in patients receiving repeated administration of C parvum, since changes in immunologic and hematologic responses may be demonstrable only after several injections. In contrast to the reported experience in adults, subcutaneous C parvum administration in children was not well tolerated, whereas intravenous infusion was generally well

ISSN:0098-1532    

DOI:10.1002/mpo.2950060203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe ectopic production of the β‐subunit of human chorionic gonadotropin (hCG) is described in a patient with an anaplastic carcinoma. After chemotherapy the marker decreased in a logarithmic fashion to undetectable levels but the neoplasm progressed and the patient died. The specificity of the β‐subunit of hCG is discussed. Discordance of the marker and clinical disease is pointed out, and several possible explanations are outlined. The lack of specificity of the β‐subunit of hCG and the discordance that it may exhibit means that its use in diagnosing and following disease progression may be

ISSN:0098-1532    

DOI:10.1002/mpo.2950060204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA case of a 10‐year‐old boy with American Burkitt lymphoma is presented in whom a 14q+ due to t(8;14)(q23;q32) was shown to exist in the ascitic lymphoma cells. This appears to be the first demonstration of such a translocation in uncultured material. In addition, another translocation involving the × chromosome, hitherto not observed in Burkitt tumors, was demonstrated. The karyotypic findings have been related to the cytogenetic experience in Burkitt and other lymphomas, with emphasis being put on the importance of the 14q+ anomaly in lymphoproliferative dise

ISSN:0098-1532    

DOI:10.1002/mpo.2950060205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractOur experience with peritoneoscopy in the postoperative staging and evaluation of ten patients with locally unresectable adenocarcinoma of the exocrine pancreas is presented. In contrast to the German experience with previously unexplored patients, the pancreas was visualized only 30% of the time and biopsy was not possible for technical reasons. Based on our experience in these ten patients, postoperative peritoneoscopy for staging or for following the effectiveness of treatment is of limited value in carcinoma of the pancreas. Preoperative evaluation of this technique deserves greater attention.

ISSN:0098-1532    

DOI:10.1002/mpo.2950060206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractLymphocyte function was evaluated in 26 untreated children with acute lymphoblastic leukemia (ALL) and 5 patients with acute myelogenous leukemia (AML) by stimulation with phytohemagglutinin (PHA) in dose‐ and time‐response studies. The response to PHA correlated positively with the percentage of lymphocytes (r = + 0.786) and negatively with the percentage of lymphoblasts (r = − 0.728).Sixteen patients with a WBC20,000/cu mm (10 ± 3% lymphocytes, 88 ± 4% lymphoblasts and 18 ± 28% T cells) had a significantly lower response to PHA on these days (13,609 ± 5,568 cpm).Six of the ten high‐WBC patients had a delayed peak response on the sixth or seventh day of culture. This abnormal response to PHA is similar to that which has been described in patients with chronic lymphatic leukemia and is at least partially due to the dilution of a normal lymphocyte population by the proliferation of a population of non‐PHA‐responsive lymphoblasts.The remaining four high‐WBC patients had flat PHA dose‐ and time‐response curves and a poorer clinical course. Two of them had T‐cell leukemia. The absence of response to PHA in these children may characterize a group of patients with acute lymphoblastic leukemia who are immunodeficient at the time of diagnosis and may reflect the presence of a unique population of lymphoblas

ISSN:0098-1532    

DOI:10.1002/mpo.2950060207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe immunologic classification of acute lymphoblastic leukemia (ALL) based solely on peripheral blood (PB) cell phenotypes may lead to conflicting results. This was demonstrated by the simultaneous assay of five immunologic markers on PB and bone marrow (BM) cells from 13 children with untreated ALL. We assayed erythrocyte (E) rosettes at 4°C and 37°C, presence of membrane Ig(mIg), and binding of antisera raised against thymus (T), and E−ALL blasts, respectively. At diagnosis, the PB of these children contained>90% lymphoid cells with 0–48% E rosettes and 1‐84% cells with T antigen(s). Of 7 children with WBC10,000/cu mm there were only 2 who had more than 20% E rosettes and T‐antigen‐positive cells. Based on examination of PB alone, six children may have been classified as having T‐like ALL. However, these results were due to the presence of circulating normal T lymphocytes, and assay of BM cells established that only one of the 13 children had T‐like ALL and none had B‐cell ALL. Bone marrow blasts from 12 patients did not form rosettes at 37°C, did not have mIg, and did not react with anti‐T serum. A high proportion of BM blasts from these 12 patients (39‐96%) did react with antiserum against E−ALL blasts. Of these 12 patients 11 had a higher proportion of E−ALL antiserum‐positive blasts in the BM than PB. Thus, immunologic classification of ALL should be based on the study of BM

ISSN:0098-1532    

DOI:10.1002/mpo.2950060208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractEleven patients with acute lymphocytic leukemia in relapse were treated with L‐asparaginase and cytosine arabinoside (1‐β‐D‐arabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 16, and 78+ weeks. One patient experienced partial remission and four had decreased bone marrow or peripheral blasts but were not clinically improved. The responses, which were brief, lasted 1‐16 weeks with one exception of 78+ weeks. Four patients had allergic reactions to L‐asparaginase that were unpredictable with assays of antibodies against L

ISSN:0098-1532    

DOI:10.1002/mpo.2950060209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe eyes of 60 children who had died of acute leukemia between 1968 and 1977 at the Children's Hospital Medical Center have been examined pathologically. An attempt has been made to relate eye findings to the state of the systemic disease at the time of death. Eight of the 60 patients had leukemic retinal infiltrates and all eight had fulminant disease with terminal leukocyte counts over 100,000 per cubic millimeter and a high percentage of „blast”︁ cells. Twenty‐six patients (43%) had leukemic infiltration of the choroid that was inapparent clinically. Choroidal involvement was not correlated with high terminal leukocyte counts but was invariably associated with widespread infiltration of other organs. Four patients had optic nerve involvement; all four had coexistent meningeal leukemia. Isolated retinal hemorrhages could not be correlated with other parameters of the leukemic

ISSN:0098-1532    

DOI:10.1002/mpo.2950060210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractDuring the past 10‐15 years there has not been a significant improvement in the overall survival of children with metastatic neuroblastoma. From 1971 through 1975, 104 eligible patients were entered on two clinical studies for newly diagnosed cases of stage IV neuroblastoma by the Childrens Cancer Study Group (CCSG). Patient data from both studies were evaluated for activity of cyclophosphamide, imidazole carboxamide, and vincristine and of these same agents plus adriamycin. Response was evaluated by serial measurements of tumor size. Eighty‐four patients experienced a complete or partial response. The life‐table estimate of median survival on both studies was 11–12 months for all patients and 13‐18 months for responders, unchanged from the results of previous CCSG studies. Long‐term survival, however, for patients on these studies demonstrates a significant increase compared with results reported from the three previous CCSG studies. Children less than 1 year or greater than 6 years of age at diagnosis showed a significantly improved survival pattern over the intermediate age group. It is suggested that there is a need to consider the induction response pattern and age at diagnosis when planning a maintenance program so that nonresponders can be identified early and considered for treatment with new agents or aggressive multimo

ISSN:0098-1532    

DOI:10.1002/mpo.2950060211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY