摘要:

AbstractThe results of follow‐up of 143 patients with malignant gastrointestinal tumors (stomach, 63 patients; colon, 13 patients; rectum, 67 patients) who have undergone radical operations are analyzed. The number of men and women among the examined patients was approximately equal, the age range was from 32 to 61 years, the length of follow‐up was from three months to one and one‐half years. The patients were regularly examined and questioned at the inpatient and outpatient departments by a surgeon and a psychiatrist.The analysis revealed marked psychogenic reactions, having different clinical forms, in patients of the oncological clinics in connection with a severe stress situation. In most of the cases these reactions were extremely extensive, and the patients were in need of specialized medical assistance (participation of a psychiatrist in their treatment). It is expedient to identify patients with marked psychogenic reactions for special treatment at the time of their acceptance to the clinic. The postoperative period of such patients was accompanied by complications in 58.5% of cases, in comparison with 12.5% in patients with mild psychogenic reactions.After discharge 31 of 62 patients found themselves in a conflict family situation, 24 patients were rather limited in their social contacts; the majority of these patients were not working after the operation.These findings indicate the need for psychotherapeutic support in oncology, plus psychopreventive measures and medical educational propaganda among the population as important components of rehabilitation pro

ISSN:0098-1532    

DOI:10.1002/mpo.2950070202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiate

ISSN:0098-1532    

DOI:10.1002/mpo.2950070203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA six‐year‐old girl presented with clinical signs and symptoms of right‐sided heart failure. Cardiac catheterization demonstrated filling defects in both pulmonary arteries felt to represent metastatic lesions or thromboemboli. Intravenous pyelogram revealed bilateral renal masses and intrarenal obstruction. Acute renal failure was unresponsive to standard therapy. An open renal biopsy revealed Wilms tumor with favorable histology. Aggressive chemotherapy and irradiation were undertaken and renal function returned. This case adds to the heterogeneity of presentations described for Wilms tumor, and review of the literature reveals no other cases with similar presenting

ISSN:0098-1532    

DOI:10.1002/mpo.2950070204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA newborn with a pleomorphic rhabdomyosarcoma of the eyelid was treated by chemotherapy, surgery, and radiation therapy and experienced a good response. The nine previous cases in the literature are reviewed and this patient's therapy discussed.

ISSN:0098-1532    

DOI:10.1002/mpo.2950070205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractIn 163 children with acute nonlymphocytic leukemia (ANLL), a D‐ZAPO induction program consisting of daunomycin, 5‐azacytidine, cytosine arabinoside, prednisone, and vincristine resulted in a remission rate of 71.8%. Immunologic therapy was employed during maintenance with the aim of prolonging remission and improving survival. The administration of immunotherapy consisting of a mixture of bacillus Calmette‐Guérin (BCG) and allogeneic acute myelomonocytic leukemic cells injected intradermally on day 14 of each of the first three monthly cycles of 6‐thioguanine for ten days, 5‐azacytidine and cytosine arabinoside for four days, and vincristine for one day did not improve remission duration or survival compared to that due to chemotherapy alone. Important prognostic factors identified in this study included a remission induction rate significantly better for females than males (P = 0.04), for children between the ages of 5 and 10 years compared to those greater than this age group (P = 0.01), and a prolonged remission duration (P = 0.04), and survival (P<0.01) for patients with initial white blood counts of<20

ISSN:0098-1532    

DOI:10.1002/mpo.2950070206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractIn an attempt to identify possible adverse effects of CNS prophylaxis (cranial radiation and intrathecal chemotherapy), we examined hypothalamic‐pituitary function in 23 patients with acute lymphocytic leukemia (ALL). Of 18 patients who had received both cranial radiation and intrathecal chemotherapy, nine had abnormally low growth hormone responses to insulin‐induced hypoglycemia (<7.0 ng/ml). Seven of the nine patients with abnormally low growth hormone responses also mainfested ventricular dilatation on computed tomography (CT) brain scans, whereas only one of the nine patients with normal growth hormone responses demonstrated this CT scan finding (P = 0.015). The remaining patients, who had not received cranial radiation, had normal growth hormone responses and normal CT scans. There is a significant correlation between ventricular dilatation on CT and abnormally low peak growth hormone responses following CNS prophylaxis in

ISSN:0098-1532    

DOI:10.1002/mpo.2950070207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThirteen children with localized (Evans stage I or II) thoracic primary neuroblastoma were divided into two groups according to the type of therapy administered, in order to compare the therapeutic efficacy and morbidity of excisional surgery followed by either irradiation alone or irradiation plus chemotherapy (group A) with similar surgery alone (group B). Group A consisted of 6 children (mean age 1 year, 2 months). Complete surgical excision was accomplished in 2 patients, while 4 had microscopic residual. All 6 patients are free of disease at 23–76 months (mean 47 months), including 2 who had recurrent tumor and received additional therapy. Two have developed congestive heart failure and one severe scoliosis secondary to irradiation.Of the 7 children in group B (mean age 2 years, 2 months), 3 had microscopic residual tumor and 2 had adjacent lymph node involvement. After 12–47 months (mean 23 months), no recurrence or surgery‐related morbidity has been observed. From these limited data it appears that surgery alone may provide adequate therapy for localized thoracic neuroblastoma and obviate the morbidity associated with multimodal th

ISSN:0098-1532    

DOI:10.1002/mpo.2950070208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA 12 1/2‐year‐old female presented with Ewing's sarcoma of the manubrium sterni which extended into the anterior mediastinum. At presentation there was no evidence of metastatic disease. Her initial treatment consisted of radiation therapy and chemotherapy. The residual tumor was subsequently resected and the sternal defect was repaired with Marlex mesh. Post‐operatively, she was maintained on chemotherapy consisting of BCNU, cyclophosphamide, and adriamycin. The adriamycin was discontinued after she developed sterile fibrinous pericarditis. She remains free of her disease two years after diagnosis. Although extremely rare, Ewing's does occur in the sternum and this area is amenable to wide local resection without severe functional disab

ISSN:0098-1532    

DOI:10.1002/mpo.2950070209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractRapid tumor lysis may produce acute complications including systemic metabolic disturbances and hemorrhage in sites involved by tumor. We have observed two cases of acute pancreatitis induced by the lysis of lymphoma that involved the pancreas. This previously unreported cause of pancreatitis must be added to the list of potential complications associated with effective cancer chemotherapy.

ISSN:0098-1532    

DOI:10.1002/mpo.2950070210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe protection of human subjects in research is a shared responsibility. The informed consent procedure was introduced to implement protection of the subjects. The contents of consent forms have been in dispute, and the impact of the procedure on the human subject has caused concern. It was demonstrated that patients with cancer have poor recall of the contents of a signed consent form.

ISSN:0098-1532    

DOI:10.1002/mpo.2950070211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY