ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

A critical review of the neuropathology associated with seizures is presented, with special reference to the damage to the brain claimed to result from electroconvulsive treatment (ECT). From the point of view of neuron loss, there is no evidence that single seizures (convulsions), even if repeated, result in this type of damage to the brain, which is the only definitely irreversible kind. Pitfalls of the methods of investigation available in neuropathology are described to support this statement. Basic differences between epileptic seizures and induced seizures are emphasized in relation to neuron loss in epilepsy.

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

The effects of ECT on 5-hydroxyindoleacetic acid, homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol in cerebrospinal fluid and on kinetic parameters of platelet serotonin uptake were studied in 12 patients with melancholia. There were no significant changes in the monoamine metabolites 3 weeks after initiation of ECT in 12 patients; however, there was a tendency for HVA to increase. The Vmaxof serotonin uptake (measured in seven patients) remained unchanged after ECT, but there was a significant increase in Km, indicating a decreased affinity for serotonin in the carrier.

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Study of serum prolactin during electroconvulsive therapy (ECT) in depressive patients revealed a greater prolactin increase after bilateral than after unilateral ECT. A linear correlation between the two types of prolactin response was found for a group of 10 patients, a finding that suggests a quantitative rather than a qualitative difference between bilateral and unilateral ECT with regard to their prolactin-releasing properties. The magnitude of prolactin response did not differ between right and left unilateral ECT, nor in a systematically studied case of postictal dysphoric excitement that occurred after right, but not after left, unilateral ECT. In this case, maximal prolactin response occurred earlier with right than with left unilateral ECT. Prolactin increase after ECT was not correlated with such factors as severity of depression nor seizure duration.

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

The ability to predict treatment response in patients administered electroconvulsive therapy remains limited. Variables such as the duration of the individual seizure or the cumulative seizure duration have been reported to relate to outcome in a “threshold” or “therapeutic window” model. In this study, total seizure time, as measured by bifrontal electroencephalogram (EEG) electrodes, did correlate with outcome (rs= 0.43, p < 0.01). In addition, 88% of patients with a cumulative seizure time exceeding 300 s responded favorably (X2= 6.80, ñ < 0.01). This provides support for the concept of a minimum threshold of accumulated seizure time necessary for clinical response. However, no evidence of an upper limit of benefit suggesting a "therapeutic window" was found.

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

摘要:

Seizure monitoring using an auditory representation of the electroencephalogram (EEG) was tested in 82 consecutive electroconvulsive treatments (ECTs). It was found to have high interrater and intrarater reliability and high validity against the paper EEG standard.

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID

ISSN:0749-8055    

出版商:OVID    

年代:1986

数据来源: OVID