摘要:

SUMMARYHypothalamic, pituitary and gonadal function was studied in five male and three female patients with the Prader‐Willi syndrome. All were clinically hypogonadal: all males had low circulating testosterone levels, although in two females basal plasma oestradiol was within the normal range for the early follicular phase of the menstrual cycle. Basal gonadotrophin levels were low and the response to the intravenous administration of LHRH was subnormal in seven. Repeat administration of LHRH after 10 days and 6 weeks treatment with oral clomiphene (200 mg daily) was followed by a normal rise in luteinizing hormone (LH) and follicle stimulating hormone (FSH) in four out of five patients tested. All five males were tested with human chorionic gonadotrophin (hCG) and the rise in plasma testosterone was subnormal in four. Treatment with hCG was continued for 6 weeks in these four patients, but in only one did testosterone levels rise (transiently) to the normal adult male range. In one female patient studied no rise in plasma oestradiol was detected in response to human menopausal gonadotrophin (hMG). These results suggest that the hypogonadism in the Prader‐Willi syndrome is due to combined hypothalamic and primary gonadal abnormalit

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03136.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummarySynthetic LHRH (HOE 471) administered intranasally over a period of 4 weeks for treatment of uni‐ or bilateral cryptorchidism in nineteen otherwise healthy prepubertal boys led to increased basal and peak LH values and to markedly decreased peak FSH values in the i.v. LHRH test. Basal testosterone remained unchanged. Sixteen cryptorchid boys treated with placebo served as a control group. The reduced FSH response to i.v. LHRH could be due to induction of a gonadal feedback mechanism rather than pituitary depletion of FSH, in view of the favourable therapeutic effect and the increased LH secretion seen in some of our patients. Pretreatment LHRH tests were available in twenty successfully and in twenty‐eight unsuccessfully treated boys. LH values were similar in both groups, whereas FSH peak values were significantly higher in boys who responded successfully to subsequent therapy. Testicular descent occurred most readily in boys with a large pool of easily releasable FSH and without a significant rise in testosterone (in contrast to HCG treatment). We suggest that FSH induces changes that potentiate the local action of testoster

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03137.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryAntidiuretic hormone (ADH) immunoactivity (28–164 pg/mg wet weight) was detected in the tumour tissue of only three out of thirty‐two patients with carcinoma of the bronchus. All three patients had small oat‐cell tumours and two had persistent hyponatraemia prior to death. Serum sodium was not obtained in the third patient. Serum sodium was normal in the remaining twenty‐nine patients with undetectable ADH immunoa

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03138.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Book Reviewed in this article:The regulation of growth hormone secretionContemporary metabolism

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03139.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03140.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03125.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY