摘要:

SUMMARYFree T4 and free T3 concentrations in thyrotoxic and hypothyroid patients at presentation differentiated those with thyroid disease from euthyroid control subjects and were closely correlated with T4/TBG ratio. A further group of thyrotoxic patients was followed serially during treatment with carbimazole. Measurements of free T4 and free T3 against closely reflected thyroid status with changes in the hormone measurements being paralleled by changes in T4/TBG ratio.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1984.tb00064.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

SUMMARYDisappearance of immunoreactive ovine corticotrophin‐releasing factor (IR‐oCRF) from plasma after a single intravenous injection of ovine corticotrophinreleasing factor (oCRF) was studied in man in the morning and evening. Synthetic oCRF (80 μg) was injected intravenously to four normal male volunteers at 0900 h or at 2200 h. Blood samples were drawn before and 2, 5, 10, 15, 30, 45, 60, 90 and 120 min after the oCRF injection. Plasma IR‐oCRF was measured by a specific radioimmunoassay for OCRF. Plasma concentrations of IR‐oCRF after oCRF injections in the morning and in the evening did not differ significantly (P>0·05). Disappearance of IR‐oCRF was modelled with a two‐exponent function by using a non‐linear least squares computer program. The metabolic clearance rate, the apparent initial volume of distribution, the plasma half‐life for the fast component and that for the slow component calculated from all eight tests in the morning and evening were 1·49·0±05 ml/min·kg, 44·4±1·7 ml/kg, 6·8±0·7 min and 46·2±2·3 min (mean ± SEM), respectively. This relatively long half‐life may be responsible for the prolonged biological effect of oCRF administered intravenously. There were no significant differences between parameters of IR‐oCRF disappearance curves in the mornin

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1984.tb00065.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY