摘要:

SUMMARYEight male patients with hypogonadotrophic hypogonadism were treated with injections of a long acting LHRH analogue, HOE 766. Six of the patients were on daily subcutaneous injections of 5 μgof this analogue at the start of this study and were changed to alternate‐daily injections of the same dose for 1–3 months. They were then treated with twice‐daily injections of 0·5 μgHOE 766, as was another subject not previously treated. The HOE 766 twice‐daily was given alone for 1 or 2 months and then sex steroid replacement therapy was added to this for a further 4–5 months. There was no clinical improvement or rise in plasma testosterone levels until sex steroid therapy was commenced. Basal LH and FSH levels and peak responses to 100 μgLHRH remained low throughout the study. It is concluded that these variations in dose and interval of administration do not overcome the lack of pituitary response which is a feature of prolonged treatment with L

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00369.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY. A patient with the resistant ovary syndrome is reported. It is suggested that lack of synchronization between steroidogenesis in the granulosa and theca cells is responsible for the (acquired) occurrence of this syndrome. Feedback inhibition of pituitary gonadotrophin secretion was achieved by exogenously administered ovarian steroid hormones. All protein and steroid hormone levels returned to normal and spontaneous ovulatory cycles returned after withdrawal of medication. It is concluded that the so called‘resistant ovary syndrome’is not an irreversible proc

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00370.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

SUMMARY. Spironolactone alone in full dosage failed to correct hypertension in a patient with Conn's syndrome and renal impairment, although the previously increased total exchangeable sodium fell to normal and the previously suppressed plasma angiotensin II did not rise above the normal range. Addition of the converting enzyme inhibitor captopril reduced plasma angiotensin II to very low levels, with a slight further fall in exchangeable sodium. Blood pressure was well controlled. Because hypertension in Conn's syndrome resistant to spironolactone usually also responds poorly to removal of the adenoma, and is difficult to treat with conventional hypotensive agents, the combination of a converting enzyme inhibitor with a potassium conserving diuretic is worthy of trial in such cases.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00371.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1981.tb00372.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY