摘要:

SUMMARYHormonal and cardiovascular responses to 1‐desamino‐8‐d‐arginine vasopressin (DDAVP) were investigated in six normal adult volunteers. After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 μg/kg) or the same volume of normal saline was administered. One hour later an intravenous infusion of hypertonic saline was commenced and continued over two hours. Five minutes following the DDAVP injection, facial flushing, a fall in diastolic blood pressure by an average of 13% and a rise in pulse rate by an average of 18% were observed. There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH. Following osmotic stimulation by hypertonic saline plasma AVP rose to the same extent in both the DDAVP and control studies. DDAVP (0.4 μg/kg) was also administered to five subjects with cranial diabetes insipidus. Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endog

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1986.tb03258.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYIn order to investigate the possible role of oxytocin in osmoregulation and its response to stress, plasma immunoreactive oxytocin was measured during hypertonic saline infusion and insulin‐induced hypoglycaemia in a group of normal subjects, four patients with idiopathic diabetes insipidus and one patient with DIDMOAD syndrome (the syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness). The results were compared with those of plasma immunoreactive vasopressin to the same stimuli. As expected, there was a rise in plasma vasopressin in the normal subjects to both tests: this was absent in the patients with diabetes insipidus. Plasma oxytocin did not rise during hypertonic saline infusion in either group of subjects. The response of oxytocin to insulin‐induced hypoglycaemia (0.15 U/kg soluble insulin) in normal subjects was much more variable. One highly symptomatic volunteer showed a marked rise in oxytocin. Two subjects also showed a rise when retested with 0.19 U/kg soluble insulin. There was no response of oxytocin to a standard‐dose insulin test in the patients with diabetes insipidus. The data suggest that, in man, oxytocin is not involved in osmoregulation but that it may be secreted in response to marked hypoglyc

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1986.tb03259.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

SUMMARYAmiodarone was given by daily intraperitoneal injection (10 mg/kg body weight) to a group of 11 New Zealand white rabbits. Over 6 weeks there were significant increases (P<0–01) in plasma total T4 concentration (43±8 to 60±13 nmol/1; mean±l SD) and rT3 concentration (0.12±0.06 to 0.31 ± 0.16 nmol/1) and a significant fall in total plasma T3 (2.3±0.3 to 1.7 ± 0.2 nmol/1). The plasma clearance of T4 in rabbits treated with amiodarone for 6 weeks was significantly reduced relative to controls (64 ± 25 vs 109 ± 19 ml/kg per day,P<0.01) but the production rate was unchanged (3.8±1.8 vs 3.7±1.4 nmol/kg per day). In the amiodarone treated animals the increased plasma T4 concentration was entirely accounted for by the reduced clearance. It is inferred that the normal output of T4 by the thyroid is pituitary dependent and that TSH secretion is sustained in the presence of hyperthyroxinaemia because of amiodarone induced partial inhibition of T4 utilization by th

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1986.tb03260.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1986.tb03261.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Book Review in this ArticlesHormonal Control of the Hypothalamo‐Pituitary‐Gonadal Axis. Edited by K. W. McKerns&Z. Naor.Gossypol: A Potential Contraceptive for Men(Reproductive Biology Series). Edited by S.J. Segal.Endocrine Aspects of Acute Illness. Edited by Geelhoed&ChernowCoping With Juvenile Diabetes. Edited by P. I. Ahmed&N. Ahmed.Current Topics in Clinical and Experimental Aspects of Diabetes Mellitus. Edited by N. Sakamoto, H. K. Min&S. B

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1986.tb03262.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY