摘要:

SUMMARYNormal men and normally menstruating women received i.m. injections of 0.1 to 4.0 mg/kg sulphide. This psychotropic drug induced a very rapid (already significant after 5 minutes) and sustained (still significant after 7 hours) elevation of prolactin (PRL) concentrations in all subjects with no consistent modification of LH and FSH. After injection of 4.0 mg/kg, there was similarly no modification of mean TSH concentrations in the women tested in the luteal phase, as well as of mean GH levels in men. Sulpiride prevented the inhibitory effect on PRL levels of 500 mg levodopa, administered orally simultaneously; levodopa administered 2 hours prior to sulpiride failed to counteract the PRL‐stimulatory effect of sulpiride. Under chronic sulpiride‐induced hyperprolactinaemia, levodopa exhibited however a very slight inhibitory effect on PRL concentrations. These data are in agreement with the hypothesis that sulpiride acts mainly at the pituitary level by blocking dopamine receptors of the lactotropes and support the concept that the menstrual cycle perturbations observed under chronic sulpiride administration result from hyperprolactinaemia itself or from a mechanism quite similar to that by which sulpiride induces hyperprolactinae

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02200.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYTo investigate the possible presence of thyroglobulin (Tg) of different molecular sizes in plasma, blood specimens were drawn from patients during and after surgery for thyroid adenoma. Tg was measured in all serum samples by a radioimmunoassay. Selected samples were fractionated on a sepharose CL‐6B column, and the fractions were assayed for Tg antigen.In serum drawn at maximum Tg concentration, molecular weights of Tg antigen ranging from 660,000 (19S) to less than 100,000 were found. 6 h later the Tg antigen of mol. wt.<100,000 could not be detected, and after 3 days only 19S Tg was present. Correspondingly the plasma Tg concentration vs. time curve showed a biphasic course from which two half‐lives could be estimated. For 19S Tg,ta1/2, had a mean value of 4.3 days, whereas the over‐all half‐life for the mixture of smaller molecules,tb1/2. had a mean value of 3.7 h.The smaller molecules also showed different antigenic reactivity in the assay indicating an altered structure of the molecules. The assumption that this might be due to lack of sialic acid would explain the faster catabolic rate.Preliminary results from this study have been presented at the 11th FEBS Meeting in Copenhagen, 1977, and at the European Thyroid Association 8th Meeting in Lyo

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02201.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYIn a study of 250 patients with autoimmune thyroid disease, seven (2.8%) were found to have polymyalgia rheumatica or giant cell arteritis. All cases occurred in female patients over the age of 60 years, a prevalence in this group of 9.3%. No cases of either disorder were seen in a control population of 150 female patients over the age of 50 years attending a cardiac clinic at the same hospital. Awareness of this association may allow earlier diagnosis and treatment of this syndrome in elderly patients with thyroid disease.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02202.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYIn four juvenile patients with Cushing's disease, the therapeutic approach used was unilateral adrenalectomy followed by irradiation of the pituitary. The follow‐up time of these patients has ranged from 1.5 to 10 years. All four are clinically well. Concentrations of adrenal steroids are within normal limits and they require no additional medication. It is felt that this method gives young patients the chance for normal growth and pubertal development as well as a normal social life, so important in the stressful adolescent years, thus avoiding the handicap incurred by bilateral adrenalectomy and the consequent requirement for continuous substitution therap

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02203.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYSix obese subjects were studied over a period of 12 weeks whilst on a 1260 kJ (300 kcal) formula diet. Weight loss was initially rapid, but later slowed markedly despite good patient compliance. The basal metabolic rate (BMR) fell in all patients during the study. Plasma triiodothyronine fell in all patients, whilst the plasma half‐life of thyroxine increased. Plasma thyroxine, reverse triiodothyronine (reverse T3) and the serum prolactin and thyrotropin response to thyroliberin all showed no significant chang

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02204.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYEvidence on pituitary‐gonadal function in XYY subjects has been inconclusive and based, for the most part, on selected samples such as institutionalized individuals or subjects examined for particular behavioural or medical characteristics. We report the results of a double‐blind hormonal study of a sample from an entire well‐defined birth cohort of men. The starting population included all males born in Copenhagen during the period 1944–1947 comprising 31,436 individuals. Chromosome determinations conducted on 4139 men representing the top 15.9% of the height distribution of the sample identified 12 XYY and 16 XXY men. All the XYY subjects and 14 XXYs consented to participate in an individual case study and were individually matched to XY controls selected from the total sample. The XYY men had significantly higher plasma concentrations of LH, FSH and testosterone than matched XY controls. There were no differences in testicular size and in the reported number of children between the XYYs and control group. XXY men from the same population showed significantly higher LH and FSH, lower concentrations of testosterone, had smaller testes and reported fewer children than their matched c

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02205.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYBasal prolactin concentrations in 357 patients with renal disease of defined pathology have been compared with those in 210 control subjects. Elevated prolactin concentrations were found in 113 renal patients (32%) including 53 patients in whom elevated concentrations were possibly attributable to drug therapy. In the remaining 60 patients who had hyperprolactinaemia not attributable to drugs, elevated concentrations (P<0.005) were found exclusively in patients with impaired renal function. A significant correlation was observed between prolactin and creatinine concentrations in these patients (r= 0.45P<0.005) and prolactin reverted towards normal after successful renal transplantation. A significant arteriovenous prolactin concentration difference across the kidney (mean 16% range 8–29%P<0.02) was found in seven patients with non‐renal non‐endocrine disease.It is concluded that the hyperprolactinaemia found commonly in patients with impaired renal function is only partly attributable to drug therapy. The positive correlation between prolactin and creatinine reversion of prolactin towards normal after successful transplantation and arteriovenous hormone concentration differences across the normal kidney suggests that the kidney has a important role in prolactin metabolism. Abnormal regulation of prolactin secretion in renal failure may also be inv

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02206.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYThe effect of acute myocardial infarction on the secretions of LH, FSH and testosterone was studied in thirteen male patients. Plasma testosterone fell transiently on the fourth day after acute myocardial infarction. This was accompanied by a rise in LH on the same day which persisted for a week after infarction. Serum FSH showed no significant change. The data suggest that following the medical stress of myocardial infarction, testosterone concentration was suppressed resulting in a compensatory rise in LH.

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02207.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYThe effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post‐operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second and fifth post‐operative day respectively and remained suppressed. Serum FSH showed no significant change. Despite a post‐operative decrease in sex hormone binding globulin (SHBG) binding capacity, non‐SHBG bound T showed a decrease parallel to T. Multiple sampling studies showed that the secretions of LH were increased and that of T were decreased post‐operatively. Following surgery, LH responses to LHRH were magnified, FSH and T responses showed no significant change when compared with the pre‐operative responses. These data suggest that secretions of LH were increased during surgery. Following surgical stress, T and E2 concentrations were suppressed resulting in a compensatory elevation of LH con

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02208.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SUMMARYThe effect of a a adrenergic blockade (phentolamine) on glucagon‐induced growth hormone response was tested in five normal men. There was no significant difference in growth hormone concentrations between the glucagon test and the glucagon‐phentolamine test (mean maximum level, 23.4 ± 3.7 ng/ml and 23.1 ± 5.9 ng/ml, respectively). Insulin secretion was significantly higher (P<0.025) 30 and 60 min after an injection of glucagon in the glucagon‐phentolamine test. The results suggest that the stimulation of growth hormone secretion by glucagon is not mediated through an a adrenergic me

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1978.tb02209.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY